Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Gamma-Aminobutyric Acid Signaling in Brown Adipose Tissue Promotes Systemic Metabolic Derangement in Obesity

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Single mRNP Analysis Reveals that Small Cytoplasmic mRNP Granules Represent mRNA Singletons

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Nodal Signaling Regulates Germ Cell Development and Establishment of Seminiferous Cords in the Human Fetal Testis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Epigenome- and Transcriptome-wide Changes in Muscle Stem Cells from Low Birth Weight Men

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Brown adipose tissue (BAT) is a metabolically active organ that contributes to the maintenance of systemic metabolism. The sympathetic nervous system plays important roles in the homeostasis of BAT and promotes its browning and activation. However, the role of other neurotransmitters in BAT homeostasis remains largely unknown. Our metabolomic analyses reveal that gamma-aminobutyric acid (GABA) levels are increased in the interscapular BAT of mice with dietary obesity. We also found a significant increase in GABA-type B receptor subunit 1 (GABA-BR1) in the cell membranes of brown adipocytes of dietary obese mice. When administered to obese mice, GABA induces BAT dysfunction together with systemic metabolic disorder. Conversely, the genetic inactivation or inhibition of GABA-BR1 leads to the re-browning of BAT under conditions of metabolic stress and ameliorated systemic glucose intolerance. These results indicate that the constitutive activation of GABA/GABA-BR1 signaling in obesity promotes BAT dysfunction and systemic metabolic derangement.

OriginalsprogEngelsk
TidsskriftCell Reports
Vol/bind24
Udgave nummer11
Sider (fra-til)2827-2837.e5
DOI
StatusUdgivet - 11 sep. 2018

ID: 56585794