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GABA agonist promoted formation of low affinity GABA receptors on cerebellar granule cells is restricted to early development

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@article{e7f98649b5dd48348ce6cd7d3ef4dbb6,
title = "GABA agonist promoted formation of low affinity GABA receptors on cerebellar granule cells is restricted to early development",
abstract = "The ability of the GABA receptor agonist 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP) to promote formation of low affinity GABA receptors on cerebellar granule cells was tested using primary cultures of these neurons. Granule cells were exposed to THIP (150 microM) for 6 hr after, respectively, 4, 7, 10 and 14 days in culture. It was found that THIP treatment of 4- and 7-day-old cultures led to formation of low affinity GABA receptors, whereas such receptors could not be detected after THIP treatment in the older cultures (10 and 14 days) in spite of the fact that these cultured granule cells expressed a high density of high affinity GABA receptors. It is concluded that the ability of THIP to promote formation of low affinity GABA receptors on cerebellar granule cells is restricted to an early developmental period.",
author = "B Belhage and Hansen, {G H} and A Schousboe and E Meier",
year = "1988",
month = "1",
day = "1",
language = "English",
volume = "6",
pages = "125--8",
journal = "International Journal of Developmental Neuroscience",
issn = "0736-5748",
publisher = "Pergamon",
number = "2",

}

RIS

TY - JOUR

T1 - GABA agonist promoted formation of low affinity GABA receptors on cerebellar granule cells is restricted to early development

AU - Belhage, B

AU - Hansen, G H

AU - Schousboe, A

AU - Meier, E

PY - 1988/1/1

Y1 - 1988/1/1

N2 - The ability of the GABA receptor agonist 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP) to promote formation of low affinity GABA receptors on cerebellar granule cells was tested using primary cultures of these neurons. Granule cells were exposed to THIP (150 microM) for 6 hr after, respectively, 4, 7, 10 and 14 days in culture. It was found that THIP treatment of 4- and 7-day-old cultures led to formation of low affinity GABA receptors, whereas such receptors could not be detected after THIP treatment in the older cultures (10 and 14 days) in spite of the fact that these cultured granule cells expressed a high density of high affinity GABA receptors. It is concluded that the ability of THIP to promote formation of low affinity GABA receptors on cerebellar granule cells is restricted to an early developmental period.

AB - The ability of the GABA receptor agonist 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP) to promote formation of low affinity GABA receptors on cerebellar granule cells was tested using primary cultures of these neurons. Granule cells were exposed to THIP (150 microM) for 6 hr after, respectively, 4, 7, 10 and 14 days in culture. It was found that THIP treatment of 4- and 7-day-old cultures led to formation of low affinity GABA receptors, whereas such receptors could not be detected after THIP treatment in the older cultures (10 and 14 days) in spite of the fact that these cultured granule cells expressed a high density of high affinity GABA receptors. It is concluded that the ability of THIP to promote formation of low affinity GABA receptors on cerebellar granule cells is restricted to an early developmental period.

M3 - Journal article

VL - 6

SP - 125

EP - 128

JO - International Journal of Developmental Neuroscience

JF - International Journal of Developmental Neuroscience

SN - 0736-5748

IS - 2

ER -

ID: 32359169