@article{fc30d98e3b2a4e05ad7f27537fdbfa04,
title = "G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans",
abstract = "Genome-wide association studies have identified several variants within the MTNR1B locus that are associated with fasting plasma glucose (FPG) and type 2 diabetes. We refined the association signal by direct genotyping and examined for associations of the variant displaying the most independent effect on FPG with isolated impaired fasting glycemia (i-IFG), isolated impaired glucose tolerance (i-IGT), type 2 diabetes, and measures of insulin release and peripheral and hepatic insulin sensitivity.",
keywords = "Adult, Aged, Blood Glucose, Denmark, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Genetic Variation, Glucose, Humans, Insulin, Insulin Resistance, Insulin-Secreting Cells, Introns, Liver, Quantitative Trait Loci, Receptor, Melatonin, MT1, Risk Factors, Twins",
author = "Thomas Spars{\o} and Am{\'e}lie Bonnefond and Ehm Andersson and Nabila Bouatia-Naji and Johan Holmkvist and Lise Wegner and Niels Grarup and Gjesing, {Anette P} and Karina Banasik and Christine Cavalcanti-Proen{\c c}a and Marion Marchand and Martine Vaxillaire and Guillaume Charpentier and Marjo-Riitta Jarvelin and Jean Tichet and Beverley Balkau and Michel Marre and Claire L{\'e}vy-Marchal and Kristine Faerch and Knut Borch-Johnsen and Torben J{\o}rgensen and Sten Madsbad and Pernille Poulsen and Allan Vaag and Christian Dina and Torben Hansen and Oluf Pedersen and Philippe Froguel",
year = "2009",
doi = "10.2337/db08-1660",
language = "English",
volume = "58",
pages = "1450--6",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",
number = "6",
}