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Fundamentals of fractional laser-assisted drug delivery: An in-depth guide to experimental methodology and data interpretation

Publikation: Bidrag til tidsskriftReviewpeer review

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In the decade since their advent, ablative fractional lasers have emerged as powerful tools to enhance drug delivery to and through the skin. Effective and highly customizable, laser-assisted drug delivery (LADD) has led to improved therapeutic outcomes for several medical indications. However, for LADD to reach maturity as a standard treatment technique, a greater appreciation of its underlying science is needed. This work aims to provide an in-depth guide to the technology's fundamental principles, experimental methodology and unique aspects of LADD data interpretation. We show that drug's physicochemical properties including solubility, molecular weight and tissue binding behavior, are crucial determinants of how laser channel morphology influences topical delivery. Furthermore, we identify strengths and limitations of experimental models and drug detection techniques, interrogating the usefulness of in vitro data in predicting LADD in vivo. By compiling insights from over 75 studies, we ultimately devise an approach for intelligent application of LADD, supporting its implementation in the clinical setting.

OriginalsprogEngelsk
TidsskriftAdvanced Drug Delivery Reviews
Vol/bind153
Sider (fra-til)169-184
Antal sider16
ISSN0169-409X
DOI
StatusUdgivet - 1 jan. 2020

Bibliografisk note

Copyright © 2019 Elsevier B.V. All rights reserved.

ID: 61763070