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Region Hovedstaden - en del af Københavns Universitetshospital
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Functional sympatholysis during exercise in patients with type 2 diabetes with intact response to acetylcholine

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Sympathetic vasoconstriction is blunted in contracting human skeletal muscles (functional sympatholysis). In young subjects, infusion of adenosine and ATP increases blood flow, and the latter compound also attenuates α-adrenergic vasoconstriction. In patients with type 2 diabetes and age-matched healthy subjects, we tested 1) the sympatholytic capacity during one-legged exercise, 2) the vasodilatory capacity of adenosine and ATP, and 3) the ability to blunt α-adrenergic vasoconstriction during ATP infusion.
OriginalsprogEngelsk
TidsskriftDiabetes Care
Vol/bind34
Udgave nummer5
Sider (fra-til)1186-91
Antal sider6
ISSN0149-5992
DOI
StatusUdgivet - 2011

ID: 33280197