Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Functional neuroimaging of recovery from motor conversion disorder: A case report

Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. Optimization of preprocessing strategies in Positron Emission Tomography (PET) neuroimaging: A [11C]DASB PET study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Disease-informed brain mapping teaches important lessons about the human brain

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  3. The role of dopamine in the brain - lessons learned from Parkinson's disease

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. No trace of phase: Corticomotor excitability is not tuned by phase of pericentral mu-rhythm

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Altered orbitofrontal sulcogyral patterns in gambling disorder: a multicenter study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

A patient with motor conversion disorder presented with a functional paresis of the left hand. After exclusion of structural brain damage, she was repeatedly examined with whole-brain functional magnetic resonance imaging, while she performed visually paced finger-tapping tasks. The dorsal premotor cortex showed a bilateral deactivation in the acute-subacute phase. Recovery from unilateral hand paresis was associated with a gradual increase in task-based activation of the dorsal premotor cortex bilaterally. The right medial prefrontal cortex displayed the opposite pattern, showing initial task-based activation that gradually diminished with recovery. The inverse dynamics of premotor and medial prefrontal activity over time were found during unimanual finger-tapping with the affected and non-affected hand as well as during bimanual finger-tapping. These observations suggest that reduced premotor and increased medial prefrontal activity reflect an effector-independent cortical dysfunction in conversion paresis which gradually disappears in parallel with clinical remission of paresis. The results link the medial prefrontal and dorsal premotor areas to the generation of intentional actions. We hypothesise that an excessive 'veto' signal generated in medial prefrontal cortex along with decreased premotor activity might constitute the functional substrate of conversion disorder. This notion warrants further examination in a larger group of affected patients.

OriginalsprogEngelsk
TidsskriftNeuroImage
Vol/bind190
Sider (fra-til)269-274
Antal sider6
ISSN1053-8119
DOI
StatusUdgivet - 15 apr. 2019

ID: 53548100