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Functional lymphatic reserve capacity is depressed in patients with a Fontan circulation

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  • Sheyanth Mohanakumar
  • Benjamin Kelly
  • Aida Luiza Ribeiro Turquetto
  • Mathias Alstrup
  • Luciana Patrick Amato
  • Milena Schiezari Ru Barnabe
  • João Bruno Dias Silveira
  • Fernando Amaral
  • Paulo Henrique Manso
  • Marcelo Biscegli Jatene
  • Vibeke Elisabeth Hjortdal
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BACKGROUND: Lymphatic abnormalities play a role in effusions in individuals with a Fontan circulation. Recent results using near-infrared fluorescence imaging disclosed an increased contraction frequency of lymphatic vessels in Fontan patients compared to healthy controls. It is proposed that the elevated lymphatic pumping seen in the Fontan patients is necessary to maintain habitual interstitial fluid balance. Hyperthermia has previously been used as a tool for lymphatic stress test. By increasing fluid filtration in the capillary bed, the lymphatic workload and contraction frequency are increased accordingly. Using near-infrared fluorescence imaging, the lymphatic functional reserve capacity in Fontan patients were explored with a lymphatic stress test.

METHODS: Fontan patients (n = 33) were compared to a group of 15 healthy individuals of equal age, weight, and gender. The function of the superficial lymphatic vessels in the lower leg during rest and after inducing hyperthermia was investigated, using near-infrared fluorescence imaging.

RESULTS: Baseline values in the Fontan patients showed a 57% higher contraction frequency compared to the healthy controls (0.4 ± 0.3 min-1 vs. 0.3 ± 0.2 min-1 , p = 0.0445). After inducing stress on the lymphatic vessels with hyperthermia the ability to increase contraction frequency was decreased in the Fontan patients compared to the controls (0.6 ± 0.5 min-1 vs. 1.2 ± 0.8 min-1 , p = 0.0102).

CONCLUSIONS: Fontan patients had a higher lymphatic contraction frequency during normal circumstances. In the Fontan patients, the hyperthermia response is dampened indicating that the functional lymphatic reserve capacity is depressed. This diminished reserve capacity could be part of the explanation as to why some Fontan patients develop late-onset lymphatic complications.

OriginalsprogEngelsk
Artikelnummere14862
TidsskriftPhysiological Reports
Vol/bind9
Udgave nummer11
Sider (fra-til)e14862
ISSN2051-817X
DOI
StatusUdgivet - jun. 2021

Bibliografisk note

© 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

ID: 68336470