Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Functional Interplay between RNA Viruses and Non-Coding RNA in Mammals

Publikation: Bidrag til tidsskriftReviewpeer review

DOI

  1. Cell type-selective expression of circular RNAs in human pancreatic islets

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Influence of Disease Duration on Circulating Levels of miRNAs in Children and Adolescents with New Onset Type 1 Diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Argonaute-CLIP delineates versatile, functional RNAi networks in Aedes aegypti, a major vector of human viruses

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Equine pegiviruses cause persistent infection of bone marrow and are not associated with hepatitis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Evolutionary selection of pestivirus variants with altered or no microRNA dependency

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Replicons of a rodent hepatitis C model virus permit selection of highly permissive cells

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Viral persistence, liver disease and host response in Hepatitis C-like virus rat model

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Exploring virus⁻host interactions is key to understand mechanisms regulating the viral replicative cycle and any pathological outcomes associated with infection. Whereas interactions at the protein level are well explored, RNA interactions are less so. Novel sequencing methodologies have helped uncover the importance of RNA⁻protein and RNA⁻RNA interactions during infection. In addition to messenger RNAs (mRNAs), mammalian cells express a great number of regulatory non-coding RNAs, some of which are crucial for regulation of the immune system whereas others are utilized by viruses. It is thus becoming increasingly clear that RNA interactions play important roles for both sides in the arms race between virus and host. With the emerging field of RNA therapeutics, such interactions are promising antiviral targets. In this review, we discuss direct and indirect RNA interactions occurring between RNA viruses or retroviruses and host non-coding transcripts upon infection. In addition, we review RNA virus derived non-coding RNAs affecting immunological and metabolic pathways of the host cell typically to provide an advantage to the virus. The relatively few known examples of virus⁻host RNA interactions suggest that many more await discovery.

OriginalsprogEngelsk
TidsskriftNon-Coding RNA
Vol/bind5
Udgave nummer1
ISSN2311-553X
DOI
StatusUdgivet - 1 jan. 2019

ID: 56289621