Functional Characterization of 5-HT1B Receptor Drugs in Nonhuman Primates Using Simultaneous PET-MR

Keyphrases

• Positron Emission Tomography 100%
• 5-HT1B Receptor 100%
• Functional Characterization 100%
• Nonhuman Primate 100%
• Hemodynamic Response 45%
• Drug Effects 27%
• Receptor Occupancy 27%
• Partial Agonist 27%
• Receptor Density 18%
• High Dose 18%
• Blood-brain Barrier 18%
• Cerebral Blood Volume 18%
• Occupancy 18%
• Brain Hemodynamics 18%
• GR127935 18%
• Receptor Binding 9%
• Serotonin 9%
• Receptor Agonist 9%
• Receptor Function 9%
• Neuronal Activity 9%
• Bolus 9%
• Sumatriptan 9%
• Extracranial 9%
• Pharmacological Intervention 9%
• Dose Effect 9%
• Magnetic Resonance Imaging 9%
• Vasoconstriction 9%
• Change of Measure 9%
• Radioligand 9%
• Constant Rate Infusion 9%
• Active Compounds 9%
• In Vivo Investigation 9%
• Barrier Passage 9%
• Contrast Injection 9%
• Temporal Effects 9%
• Agonistic 9%
• Drug Change 9%
• Drug Characteristics 9%
• Spatial Effect 9%
• CNS-active 9%
• CNS Drugs 9%

Neuroscience

• Positron Emission Tomography 100%
• 5-HT1B Receptor 100%
• Agonist 27%
• Receptor Occupancy 27%
• Blood Brain Barrier 18%
• Serotonin 9%
• Receptor Binding 9%
• In Vivo 9%
• Eicosanoid Receptor 9%
• Receptor Agonists 9%
• Magnetic Resonance Imaging 9%
• Neuronal Activity 9%
• Sumatriptan 9%
• Radioligand 9%
• Receptor Partial Agonist 9%