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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

FSHB-211 and FSHR 2039 are associated with serum levels of follicle-stimulating hormone and antimüllerian hormone in healthy girls: a longitudinal cohort study

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Vis graf over relationer
To investigate whether genetic polymorphisms in the FSH pathway (FSHB-211 G→T and FSHR 2039 A→G) affect serum levels of FSH, antimüllerian hormone (AMH), and age at pubertal onset. FSH secretion and FSH signal transduction are enhanced in carriers of FSHB GG and FSHR AA, respectively. Furthermore, the combined genotype FSHB GG+FSHR AA is the most favorable for male gonadal function, but the effect of this genotype has never been evaluated in peripubertal females. AMH is a marker of ovarian function and is negatively correlated with FSH in prepubertal girls.
OriginalsprogEngelsk
TidsskriftFertility and Sterility
Vol/bind100
Udgave nummer4
Sider (fra-til)1089-1095
ISSN0015-0282
DOI
StatusUdgivet - 11 jul. 2013

ID: 39023528