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FSHB -211 G>T Polymorphism as Predictor for TESE Success in Patients With Unexplained Azoospermia

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Busch, AS, Tüttelmann, F, Cremers, J-F, Schubert, M, Nordhoff, V, Schüring, AN, Zitzmann, M, Gromoll, J & Kliesch, S 2019, 'FSHB -211 G>T Polymorphism as Predictor for TESE Success in Patients With Unexplained Azoospermia' The Journal of clinical endocrinology and metabolism, bind 104, nr. 6, s. 2315-2324. https://doi.org/10.1210/jc.2018-02249

APA

CBE

Busch AS, Tüttelmann F, Cremers J-F, Schubert M, Nordhoff V, Schüring AN, Zitzmann M, Gromoll J, Kliesch S. 2019. FSHB -211 G>T Polymorphism as Predictor for TESE Success in Patients With Unexplained Azoospermia. The Journal of clinical endocrinology and metabolism. 104(6):2315-2324. https://doi.org/10.1210/jc.2018-02249

MLA

Vancouver

Author

Busch, Alexander Siegfried ; Tüttelmann, Frank ; Cremers, Jann-Frederik ; Schubert, Maria ; Nordhoff, Verena ; Schüring, Andreas N ; Zitzmann, Michael ; Gromoll, Jörg ; Kliesch, Sabine. / FSHB -211 G>T Polymorphism as Predictor for TESE Success in Patients With Unexplained Azoospermia. I: The Journal of clinical endocrinology and metabolism. 2019 ; Bind 104, Nr. 6. s. 2315-2324.

Bibtex

@article{03f1b6b10884487594e16c87bceebc4a,
title = "FSHB -211 G>T Polymorphism as Predictor for TESE Success in Patients With Unexplained Azoospermia",
abstract = "CONTEXT: Testicular sperm extraction (TESE) followed by assisted reproductive techniques often remains the only therapeutic option for men with azoospermia due to spermatogenic failure. Reproductive parameters, such as gonadotropin levels and testicular volume or histopathology, contribute to the prediction of sperm retrieval rate (SRR) in TESE. However, there is an eminent lack of noninvasive predictive factors for TESE outcome.OBJECTIVE: To clarify the impact of three common genetic variants affecting FSH and its cognate receptor on testicular histopathology patterns and SRR in TESE.DESIGN: We evaluated the association of the single-nucleotide polymorphisms (SNP) FSHB -211G>T (rs10835638), FSHR -29G>A (rs1394205), and FSHR c.2039A>G (rs6166) with testicular histopathology and SRR in patients with azoospermia.SETTING: Tertiary referral center for andrology.PATIENTS OR OTHER PARTICIPANTS: Men (n = 1075) with azoospermia who underwent TESE (grouped by clinical pathologies).INTERVENTION(S): All participants underwent TESE.MAIN OUTCOME MEASURE(S): Testicular histopathology, SRR, and reproductive hormone levels.RESULTS: FSHB -211G>T was significantly associated with reduced chances of sperm retrieval in patients with unexplained azoospermia. Indicating an additional mechanism, the association of the SNP with SSR could not be solely attributed to decreased FSH levels.CONCLUSION: A common genetic factor was significantly associated with SRR in TESE. In perspective, a calculator or score including the noninvasive parameters FSH level, testicular volume, and FSHB haplotype should be considered to estimate the chances for sperm retrieval in men with azoospermia.",
author = "Busch, {Alexander Siegfried} and Frank T{\"u}ttelmann and Jann-Frederik Cremers and Maria Schubert and Verena Nordhoff and Sch{\"u}ring, {Andreas N} and Michael Zitzmann and J{\"o}rg Gromoll and Sabine Kliesch",
note = "Copyright {\circledC} 2019 Endocrine Society.",
year = "2019",
doi = "10.1210/jc.2018-02249",
language = "English",
volume = "104",
pages = "2315--2324",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The/Endocrine Society",
number = "6",

}

RIS

TY - JOUR

T1 - FSHB -211 G>T Polymorphism as Predictor for TESE Success in Patients With Unexplained Azoospermia

AU - Busch, Alexander Siegfried

AU - Tüttelmann, Frank

AU - Cremers, Jann-Frederik

AU - Schubert, Maria

AU - Nordhoff, Verena

AU - Schüring, Andreas N

AU - Zitzmann, Michael

AU - Gromoll, Jörg

AU - Kliesch, Sabine

N1 - Copyright © 2019 Endocrine Society.

PY - 2019

Y1 - 2019

N2 - CONTEXT: Testicular sperm extraction (TESE) followed by assisted reproductive techniques often remains the only therapeutic option for men with azoospermia due to spermatogenic failure. Reproductive parameters, such as gonadotropin levels and testicular volume or histopathology, contribute to the prediction of sperm retrieval rate (SRR) in TESE. However, there is an eminent lack of noninvasive predictive factors for TESE outcome.OBJECTIVE: To clarify the impact of three common genetic variants affecting FSH and its cognate receptor on testicular histopathology patterns and SRR in TESE.DESIGN: We evaluated the association of the single-nucleotide polymorphisms (SNP) FSHB -211G>T (rs10835638), FSHR -29G>A (rs1394205), and FSHR c.2039A>G (rs6166) with testicular histopathology and SRR in patients with azoospermia.SETTING: Tertiary referral center for andrology.PATIENTS OR OTHER PARTICIPANTS: Men (n = 1075) with azoospermia who underwent TESE (grouped by clinical pathologies).INTERVENTION(S): All participants underwent TESE.MAIN OUTCOME MEASURE(S): Testicular histopathology, SRR, and reproductive hormone levels.RESULTS: FSHB -211G>T was significantly associated with reduced chances of sperm retrieval in patients with unexplained azoospermia. Indicating an additional mechanism, the association of the SNP with SSR could not be solely attributed to decreased FSH levels.CONCLUSION: A common genetic factor was significantly associated with SRR in TESE. In perspective, a calculator or score including the noninvasive parameters FSH level, testicular volume, and FSHB haplotype should be considered to estimate the chances for sperm retrieval in men with azoospermia.

AB - CONTEXT: Testicular sperm extraction (TESE) followed by assisted reproductive techniques often remains the only therapeutic option for men with azoospermia due to spermatogenic failure. Reproductive parameters, such as gonadotropin levels and testicular volume or histopathology, contribute to the prediction of sperm retrieval rate (SRR) in TESE. However, there is an eminent lack of noninvasive predictive factors for TESE outcome.OBJECTIVE: To clarify the impact of three common genetic variants affecting FSH and its cognate receptor on testicular histopathology patterns and SRR in TESE.DESIGN: We evaluated the association of the single-nucleotide polymorphisms (SNP) FSHB -211G>T (rs10835638), FSHR -29G>A (rs1394205), and FSHR c.2039A>G (rs6166) with testicular histopathology and SRR in patients with azoospermia.SETTING: Tertiary referral center for andrology.PATIENTS OR OTHER PARTICIPANTS: Men (n = 1075) with azoospermia who underwent TESE (grouped by clinical pathologies).INTERVENTION(S): All participants underwent TESE.MAIN OUTCOME MEASURE(S): Testicular histopathology, SRR, and reproductive hormone levels.RESULTS: FSHB -211G>T was significantly associated with reduced chances of sperm retrieval in patients with unexplained azoospermia. Indicating an additional mechanism, the association of the SNP with SSR could not be solely attributed to decreased FSH levels.CONCLUSION: A common genetic factor was significantly associated with SRR in TESE. In perspective, a calculator or score including the noninvasive parameters FSH level, testicular volume, and FSHB haplotype should be considered to estimate the chances for sperm retrieval in men with azoospermia.

U2 - 10.1210/jc.2018-02249

DO - 10.1210/jc.2018-02249

M3 - Journal article

VL - 104

SP - 2315

EP - 2324

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 6

ER -

ID: 56415691