Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

FSHB -211 G>T Polymorphism as Predictor for TESE Success in Patients With Unexplained Azoospermia

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. A Polygenic Risk Score Suggests Shared Genetic Architecture of Voice Break With Early Markers of Pubertal Onset in Boys

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Body Mass Index, Triglycerides, and Risk of Acute Pancreatitis: A Population-Based Study of 118 000 Individuals

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Gluco-Metabolic Effects of Pharmacotherapy-Induced Modulation of Bile Acid Physiology

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Effect of the incretin hormones on the endocrine pancreas in end-stage renal disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Gene Expression in Granulosa Cells From Small Antral Follicles From Women With or Without Polycystic Ovaries

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. A Polygenic Risk Score Suggests Shared Genetic Architecture of Voice Break With Early Markers of Pubertal Onset in Boys

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Using human genetics to understand the disease impacts of testosterone in men and women

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Factors affecting timing and progression of male puberty

    Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

  • Alexander Siegfried Busch
  • Frank Tüttelmann
  • Jann-Frederik Cremers
  • Maria Schubert
  • Verena Nordhoff
  • Andreas N Schüring
  • Michael Zitzmann
  • Jörg Gromoll
  • Sabine Kliesch
Vis graf over relationer

CONTEXT: Testicular sperm extraction (TESE) followed by assisted reproductive techniques often remains the only therapeutic option for men with azoospermia due to spermatogenic failure. Reproductive parameters, such as gonadotropin levels and testicular volume or histopathology, contribute to the prediction of sperm retrieval rate (SRR) in TESE. However, there is an eminent lack of noninvasive predictive factors for TESE outcome.

OBJECTIVE: To clarify the impact of three common genetic variants affecting FSH and its cognate receptor on testicular histopathology patterns and SRR in TESE.

DESIGN: We evaluated the association of the single-nucleotide polymorphisms (SNP) FSHB -211G>T (rs10835638), FSHR -29G>A (rs1394205), and FSHR c.2039A>G (rs6166) with testicular histopathology and SRR in patients with azoospermia.

SETTING: Tertiary referral center for andrology.

PATIENTS OR OTHER PARTICIPANTS: Men (n = 1075) with azoospermia who underwent TESE (grouped by clinical pathologies).

INTERVENTION(S): All participants underwent TESE.

MAIN OUTCOME MEASURE(S): Testicular histopathology, SRR, and reproductive hormone levels.

RESULTS: FSHB -211G>T was significantly associated with reduced chances of sperm retrieval in patients with unexplained azoospermia. Indicating an additional mechanism, the association of the SNP with SSR could not be solely attributed to decreased FSH levels.

CONCLUSION: A common genetic factor was significantly associated with SRR in TESE. In perspective, a calculator or score including the noninvasive parameters FSH level, testicular volume, and FSHB haplotype should be considered to estimate the chances for sperm retrieval in men with azoospermia.

OriginalsprogEngelsk
TidsskriftThe Journal of clinical endocrinology and metabolism
Vol/bind104
Udgave nummer6
Sider (fra-til)2315-2324
Antal sider10
ISSN0021-972X
DOI
StatusUdgivet - 2019

ID: 56415691