FSHB-211 and FSHR 2039 are associated with serum levels of follicle-stimulating hormone and antimüllerian hormone in healthy girls: a longitudinal cohort study

Casper P Hagen; Lise Aksglæde; Kaspar Sørensen; Annette Mouritsen; Mikkel G Mieritz; Katharina M Main; Jørgen Holm Petersen; Kristian Almstrup; Ewa Rajpert-De Meyts; Richard A Anderson; Anders Juul

doi:10.1016/j.fertnstert.2013.06.026

FSHB-211 and FSHR 2039 are associated with serum levels of follicle-stimulating hormone and antimüllerian hormone in healthy girls: a longitudinal cohort study

Casper P Hagen, Lise Aksglæde, Kaspar Sørensen, Annette Mouritsen, Mikkel G Mieritz, Katharina M Main, Jørgen Holm Petersen, Kristian Almstrup, Ewa Rajpert-De Meyts, Richard A Anderson, Anders Juul

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18 Citationer (Scopus)

Abstract

To investigate whether genetic polymorphisms in the FSH pathway (FSHB-211 G→T and FSHR 2039 A→G) affect serum levels of FSH, antimüllerian hormone (AMH), and age at pubertal onset. FSH secretion and FSH signal transduction are enhanced in carriers of FSHB GG and FSHR AA, respectively. Furthermore, the combined genotype FSHB GG+FSHR AA is the most favorable for male gonadal function, but the effect of this genotype has never been evaluated in peripubertal females. AMH is a marker of ovarian function and is negatively correlated with FSH in prepubertal girls.

Originalsprog	Engelsk
Tidsskrift	Fertility and Sterility
Vol/bind	100
Udgave nummer	4
Sider (fra-til)	1089-1095
ISSN	0015-0282
DOI	https://doi.org/10.1016/j.fertnstert.2013.06.026
Status	Udgivet - 11 jul. 2013

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10.1016/j.fertnstert.2013.06.026

Citationsformater

Hagen, C. P., Aksglæde, L., Sørensen, K., Mouritsen, A., Mieritz, M. G., Main, K. M., Petersen, J. H., Almstrup, K., Rajpert-De Meyts, E., Anderson, R. A., & Juul, A. (2013). FSHB-211 and FSHR 2039 are associated with serum levels of follicle-stimulating hormone and antimüllerian hormone in healthy girls: a longitudinal cohort study. Fertility and Sterility, 100(4), 1089-1095. https://doi.org/10.1016/j.fertnstert.2013.06.026

FSHB-211 and FSHR 2039 are associated with serum levels of follicle-stimulating hormone and antimüllerian hormone in healthy girls: a longitudinal cohort study. / Hagen, Casper P ; Aksglæde, Lise; Sørensen, Kaspar et al.
I: Fertility and Sterility, Bind 100, Nr. 4, 11.07.2013, s. 1089-1095.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Hagen, CP , Aksglæde, L, Sørensen, K, Mouritsen, A, Mieritz, MG, Main, KM , Petersen, JH , Almstrup, K , Rajpert-De Meyts, E, Anderson, RA & Juul, A 2013, 'FSHB-211 and FSHR 2039 are associated with serum levels of follicle-stimulating hormone and antimüllerian hormone in healthy girls: a longitudinal cohort study', Fertility and Sterility, bind 100, nr. 4, s. 1089-1095. https://doi.org/10.1016/j.fertnstert.2013.06.026

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title = "FSHB-211 and FSHR 2039 are associated with serum levels of follicle-stimulating hormone and antim{\"u}llerian hormone in healthy girls: a longitudinal cohort study",

abstract = "To investigate whether genetic polymorphisms in the FSH pathway (FSHB-211 G→T and FSHR 2039 A→G) affect serum levels of FSH, antim{\"u}llerian hormone (AMH), and age at pubertal onset. FSH secretion and FSH signal transduction are enhanced in carriers of FSHB GG and FSHR AA, respectively. Furthermore, the combined genotype FSHB GG+FSHR AA is the most favorable for male gonadal function, but the effect of this genotype has never been evaluated in peripubertal females. AMH is a marker of ovarian function and is negatively correlated with FSH in prepubertal girls.",

author = "Hagen, {Casper P} and Lise Aksgl{\ae}de and Kaspar S{\o}rensen and Annette Mouritsen and Mieritz, {Mikkel G} and Main, {Katharina M} and Petersen, {J{\o}rgen Holm} and Kristian Almstrup and {Rajpert-De Meyts}, Ewa and Anderson, {Richard A} and Anders Juul",

year = "2013",

month = jul,

day = "11",

doi = "10.1016/j.fertnstert.2013.06.026",

language = "English",

volume = "100",

pages = "1089--1095",

journal = "Fertility and Sterility",

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T1 - FSHB-211 and FSHR 2039 are associated with serum levels of follicle-stimulating hormone and antimüllerian hormone in healthy girls

T2 - a longitudinal cohort study

AU - Hagen, Casper P

AU - Aksglæde, Lise

AU - Sørensen, Kaspar

AU - Mouritsen, Annette

AU - Mieritz, Mikkel G

AU - Main, Katharina M

AU - Petersen, Jørgen Holm

AU - Almstrup, Kristian

AU - Rajpert-De Meyts, Ewa

AU - Anderson, Richard A

AU - Juul, Anders

PY - 2013/7/11

Y1 - 2013/7/11

N2 - To investigate whether genetic polymorphisms in the FSH pathway (FSHB-211 G→T and FSHR 2039 A→G) affect serum levels of FSH, antimüllerian hormone (AMH), and age at pubertal onset. FSH secretion and FSH signal transduction are enhanced in carriers of FSHB GG and FSHR AA, respectively. Furthermore, the combined genotype FSHB GG+FSHR AA is the most favorable for male gonadal function, but the effect of this genotype has never been evaluated in peripubertal females. AMH is a marker of ovarian function and is negatively correlated with FSH in prepubertal girls.

AB - To investigate whether genetic polymorphisms in the FSH pathway (FSHB-211 G→T and FSHR 2039 A→G) affect serum levels of FSH, antimüllerian hormone (AMH), and age at pubertal onset. FSH secretion and FSH signal transduction are enhanced in carriers of FSHB GG and FSHR AA, respectively. Furthermore, the combined genotype FSHB GG+FSHR AA is the most favorable for male gonadal function, but the effect of this genotype has never been evaluated in peripubertal females. AMH is a marker of ovarian function and is negatively correlated with FSH in prepubertal girls.

U2 - 10.1016/j.fertnstert.2013.06.026

DO - 10.1016/j.fertnstert.2013.06.026

M3 - Journal article

C2 - 23850305

SN - 0015-0282

VL - 100

SP - 1089

EP - 1095

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 4

ER -

FSHB-211 and FSHR 2039 are associated with serum levels of follicle-stimulating hormone and antimüllerian hormone in healthy girls: a longitudinal cohort study

Abstract

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