@article{a7eab9298fb441e2b196959c392e5f19,
title = "Frontal dopamine D(2/3) receptor binding in drug-naive first-episode schizophrenic patients correlates with positive psychotic symptoms and gender.",
abstract = "BACKGROUND: The aim of the study was to examine extrastriatal dopamine D(2/3) receptor binding and psychopathology in schizophrenic patients, and to relate binding potential (BP) values to psychopathology. METHODS: Twenty-five drug-naive schizophrenic patients and 20 healthy controls were examined with single-photon emission computerized tomography (SPECT) using the D(2/3)-receptor ligand [123I]epidepride. RESULTS: In the hitherto largest study on extrastriatal D(2/3) receptors we detected a significant correlation between frontal D(2/3) BP values and positive schizophrenic symptoms in the larger group of male schizophrenic patients, higher frontal BP values in male (n = 17) compared to female (n = 8) patients, and - in accordance with this - significantly fewer positive schizophrenic symptoms in the female patients. No significant differences in BP values were observed between patients and controls; the patients, however, had significantly higher BP in the right compared to the left thalamus, whereas no significant hemispheric imbalances were observed in the healthy subjects. CONCLUSIONS: The present data are the first to confirm a significant correlation between frontal D(2/3) receptor BP values and positive symptoms in male schizophrenic patients. They are in agreement with the hypothesis that frontal D(2/3) receptor activity is significant for positive psychotic symptoms. Additionally, the data support a thalamic hemispheric imbalance in schizophrenia",
keywords = "Adult, Benzamides, Brain Mapping, Brief Psychiatric Rating Scale, Case-Control Studies, Contrast Media, Female, Frontal Lobe, Humans, Iodine Isotopes, Male, Pyrrolidines, Receptors, Dopamine D2, Receptors, Dopamine D3, Schizophrenia, Schizophrenic Psychology, Sex Characteristics, Tomography, Emission-Computed, Single-Photon",
author = "Glenthoj, {Birte Y} and Torben Mackeprang and Claus Svarer and Hans Rasmussen and Pinborg, {Lars H} and Lars Friberg and Baar{\'e}, {William Frans Christian} and Hemmingsen, {Ralf Peter Arnfred} and Charlotte Videbaek",
year = "2006",
month = sep,
day = "15",
doi = "10.1016/j.biopsych.2006.01.010",
language = "English",
volume = "60",
pages = "621--629",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier Inc",
number = "6",
}