TY - JOUR
T1 - From mother to child
T2 - investigation of prenatal and postnatal exposure to persistent bioaccumulating toxicants using breast milk and placenta biomonitoring
AU - Shen, Heqing
AU - Main, Katharina M
AU - Virtanen, Helena E
AU - Damggard, Ida N
AU - Haavisto, Anne-Maarit
AU - Kaleva, M
AU - Boisen, K A
AU - Schmidt, Ida M
AU - Chellakooty, Marla
AU - Skakkebaek, Niels E
AU - Toppari, Jorma
AU - Schramm, Karl-Werner
PY - 2007/4
Y1 - 2007/4
N2 - The exposure levels of placenta and paired breast milk samples to selected organochlorine compounds and pesticides from Danish and Finnish samples have been investigated. p,p'-DDE is the dominant pollutant, beta-HCH, hexachlorobenzene, endosulfan-I, dieldrin, oxychlordane, cis-heptachlor epoxide and p,p'-DDT being the other major constituents. Their concentrations are linearly correlated between milk and placenta in similar patterns for Danish and Finnish samples. Milk samples have higher levels of these pollutants than placenta on lipid base. However, the apparently not correlated compounds, such as alpha-HCH, pentachlorobenzene, pentachloroanisole and methoxychlor, are generally accumulated more in placenta, which may suggest a tissue specific metabolic activity. Thus, depending on the compound of interest, biomonitoring may be done in placenta only or in both matrices.
AB - The exposure levels of placenta and paired breast milk samples to selected organochlorine compounds and pesticides from Danish and Finnish samples have been investigated. p,p'-DDE is the dominant pollutant, beta-HCH, hexachlorobenzene, endosulfan-I, dieldrin, oxychlordane, cis-heptachlor epoxide and p,p'-DDT being the other major constituents. Their concentrations are linearly correlated between milk and placenta in similar patterns for Danish and Finnish samples. Milk samples have higher levels of these pollutants than placenta on lipid base. However, the apparently not correlated compounds, such as alpha-HCH, pentachlorobenzene, pentachloroanisole and methoxychlor, are generally accumulated more in placenta, which may suggest a tissue specific metabolic activity. Thus, depending on the compound of interest, biomonitoring may be done in placenta only or in both matrices.
KW - Adult
KW - Denmark
KW - Dichlorodiphenyl Dichloroethylene
KW - Environmental Monitoring
KW - Environmental Pollutants
KW - Female
KW - Finland
KW - Humans
KW - Hydrocarbons, Chlorinated
KW - Infant, Newborn
KW - Insecticides
KW - Male
KW - Milk, Human
KW - Mothers
KW - Pesticides
KW - Placenta
KW - Pregnancy
KW - Prenatal Exposure Delayed Effects
U2 - 10.1016/j.chemosphere.2006.05.106
DO - 10.1016/j.chemosphere.2006.05.106
M3 - Journal article
C2 - 17207515
VL - 67
SP - S256-62
JO - Chemosphere
JF - Chemosphere
SN - 0045-6535
IS - 9
ER -