Fresh-frozen plasma resuscitation after traumatic brain injury and shock attenuates extracellular nucleosome levels and deoxyribonuclease 1 depletion

Martin Sillesen; Guang Jin; Rahmi Oklu; Hassan Albadawi; Ayesha M Imam; Cecilie H Jepsen; John O Hwabejire; Sisse R Ostrowski; Pär I Johansson; Lars S Rasmussen; Hasan B Alam

doi:10.1016/j.surg.2013.04.002

Fresh-frozen plasma resuscitation after traumatic brain injury and shock attenuates extracellular nucleosome levels and deoxyribonuclease 1 depletion

Martin Sillesen, Guang Jin, Rahmi Oklu, Hassan Albadawi, Ayesha M Imam, Cecilie H Jepsen, John O Hwabejire, Sisse R Ostrowski, Pär I Johansson, Lars S Rasmussen, Hasan B Alam

22 Citationer (Scopus)

Abstract

Traumatic brain injury and shock are among the leading causes of trauma-related mortality. We have previously shown that fresh-frozen plasma (FFP) resuscitation reduces the size of brain lesion and associated swelling compared with crystalloids. We hypothesized that this effect would be associated with an attenuation of circulating nucleosome levels, a biomarker of injury with cytotoxic potential, through reconstitution of circulating deoxyribonuclease-1 (DNAse1), an enzyme identified as critical in nucleosome clearance from the circulation.

Originalsprog	Engelsk
Tidsskrift	Surgery
Vol/bind	154
Udgave nummer	2
Sider (fra-til)	197-205
Antal sider	9
ISSN	0263-9319
DOI	https://doi.org/10.1016/j.surg.2013.04.002
Status	Udgivet - aug. 2013

Adgang til dokumentet

10.1016/j.surg.2013.04.002

Citationsformater

Sillesen, M., Jin, G., Oklu, R., Albadawi, H., Imam, A. M., Jepsen, C. H., Hwabejire, J. O., Ostrowski, S. R., Johansson, P. I., Rasmussen, L. S., & Alam, H. B. (2013). Fresh-frozen plasma resuscitation after traumatic brain injury and shock attenuates extracellular nucleosome levels and deoxyribonuclease 1 depletion. Surgery, 154(2), 197-205. https://doi.org/10.1016/j.surg.2013.04.002

Sillesen, M, Jin, G, Oklu, R, Albadawi, H, Imam, AM, Jepsen, CH, Hwabejire, JO, Ostrowski, SR , Johansson, PI , Rasmussen, LS & Alam, HB 2013, 'Fresh-frozen plasma resuscitation after traumatic brain injury and shock attenuates extracellular nucleosome levels and deoxyribonuclease 1 depletion', Surgery, bind 154, nr. 2, s. 197-205. https://doi.org/10.1016/j.surg.2013.04.002

@article{b447bb857e3d45fdaeb843915ad9f240,

title = "Fresh-frozen plasma resuscitation after traumatic brain injury and shock attenuates extracellular nucleosome levels and deoxyribonuclease 1 depletion",

abstract = "Traumatic brain injury and shock are among the leading causes of trauma-related mortality. We have previously shown that fresh-frozen plasma (FFP) resuscitation reduces the size of brain lesion and associated swelling compared with crystalloids. We hypothesized that this effect would be associated with an attenuation of circulating nucleosome levels, a biomarker of injury with cytotoxic potential, through reconstitution of circulating deoxyribonuclease-1 (DNAse1), an enzyme identified as critical in nucleosome clearance from the circulation.",

author = "Martin Sillesen and Guang Jin and Rahmi Oklu and Hassan Albadawi and Imam, {Ayesha M} and Jepsen, {Cecilie H} and Hwabejire, {John O} and Ostrowski, {Sisse R} and Johansson, {P{\"a}r I} and Rasmussen, {Lars S} and Alam, {Hasan B}",

year = "2013",

month = aug,

doi = "10.1016/j.surg.2013.04.002",

language = "English",

volume = "154",

pages = "197--205",

journal = "Surgery",

issn = "0263-9319",

publisher = "Elsevier Limited",

number = "2",

}

TY - JOUR

T1 - Fresh-frozen plasma resuscitation after traumatic brain injury and shock attenuates extracellular nucleosome levels and deoxyribonuclease 1 depletion

AU - Sillesen, Martin

AU - Jin, Guang

AU - Oklu, Rahmi

AU - Albadawi, Hassan

AU - Imam, Ayesha M

AU - Jepsen, Cecilie H

AU - Hwabejire, John O

AU - Ostrowski, Sisse R

AU - Johansson, Pär I

AU - Rasmussen, Lars S

AU - Alam, Hasan B

PY - 2013/8

Y1 - 2013/8

N2 - Traumatic brain injury and shock are among the leading causes of trauma-related mortality. We have previously shown that fresh-frozen plasma (FFP) resuscitation reduces the size of brain lesion and associated swelling compared with crystalloids. We hypothesized that this effect would be associated with an attenuation of circulating nucleosome levels, a biomarker of injury with cytotoxic potential, through reconstitution of circulating deoxyribonuclease-1 (DNAse1), an enzyme identified as critical in nucleosome clearance from the circulation.

AB - Traumatic brain injury and shock are among the leading causes of trauma-related mortality. We have previously shown that fresh-frozen plasma (FFP) resuscitation reduces the size of brain lesion and associated swelling compared with crystalloids. We hypothesized that this effect would be associated with an attenuation of circulating nucleosome levels, a biomarker of injury with cytotoxic potential, through reconstitution of circulating deoxyribonuclease-1 (DNAse1), an enzyme identified as critical in nucleosome clearance from the circulation.

U2 - 10.1016/j.surg.2013.04.002

DO - 10.1016/j.surg.2013.04.002

M3 - Journal article

C2 - 23889948

SN - 0263-9319

VL - 154

SP - 197

EP - 205

JO - Surgery

JF - Surgery

IS - 2

ER -

Fresh-frozen plasma resuscitation after traumatic brain injury and shock attenuates extracellular nucleosome levels and deoxyribonuclease 1 depletion

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater