Abstract
We have investigated the frequency of the delta F508 mutation on cystic fibrosis (CF) chromosomes in Denmark. Of 304 chromosome tested, 86.8% have the delta F508 mutation. The majority of the chromosomes with this mutation are found on chromosomes with the XV2c/KM19 haplotype B (97.3%), whereas 15/16 chromosomes with haplotype C have another mutation, confirming that only very few mutations will account for the majority of CF genes in the Danish population.
Originalsprog | Engelsk |
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Tidsskrift | Human Genetics |
Vol/bind | 85 |
Udgave nummer | 4 |
Sider (fra-til) | 427-8 |
Antal sider | 2 |
ISSN | 0340-6717 |
DOI | |
Status | Udgivet - sep. 1990 |
Udgivet eksternt | Ja |