Frequency of the delta F508 mutation on cystic fibrosis chromosomes in Denmark

M Schwartz, H K Johansen, C Koch, N J Brandt

49 Citationer (Scopus)

Abstract

We have investigated the frequency of the delta F508 mutation on cystic fibrosis (CF) chromosomes in Denmark. Of 304 chromosome tested, 86.8% have the delta F508 mutation. The majority of the chromosomes with this mutation are found on chromosomes with the XV2c/KM19 haplotype B (97.3%), whereas 15/16 chromosomes with haplotype C have another mutation, confirming that only very few mutations will account for the majority of CF genes in the Danish population.

OriginalsprogEngelsk
TidsskriftHuman Genetics
Vol/bind85
Udgave nummer4
Sider (fra-til)427-8
Antal sider2
ISSN0340-6717
DOI
StatusUdgivet - sep. 1990
Udgivet eksterntJa

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