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Freeze-dried plasma in major haemorrhage: a systematic review

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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BACKGROUND AND OBJECTIVES: Freeze-dried plasma (FDP) has logistical advantages in terms of storage and reconstitution time compared to fresh-frozen plasma. In vitro studies show FDP to be equivalent to fresh-frozen plasma regarding coagulation and clotting capacities. FDP is used in an increasing number of countries. We wanted to evaluate the clinical effects of FDP in major haemorrhage compared to standard care.

METHODS: MEDLINE, Embase, Central, Biosis Previews, WHO ICTRP, Clinical Trials and Open Grey were systematically searched from inception until September 2018, without language restriction. Studies were eligible if they examined haemorrhagic adult patients transfused with FDP. Our primary outcome was mortality. Two reviewers independently assessed studies for eligibility, extracted data and assessed bias.

RESULTS: Nine studies were eligible for inclusion. Three studies had a comparison group: one was a randomized controlled trial and two were before and after comparisons. Six studies were uncontrolled. A total of 606 patients received FDP, while 72 patients received non-FDP transfusion. In total, five minor adverse effects were documented. Two studies compared FDP to fresh-frozen plasma and found no difference in 30-day mortality between the groups. The included studies were heterogenous and had several methodological weaknesses, such as no control group, missing data or no protocol.

CONCLUSIONS: The available research does not document the clinical effects of FDP. We cannot recommend or discourage use of FDP in major haemorrhage on base of available research.

OriginalsprogEngelsk
TidsskriftVox Sanguinis
Vol/bind115
Udgave nummer4
Sider (fra-til)263-274
Antal sider12
ISSN0042-9007
DOI
StatusUdgivet - maj 2020

Bibliografisk note

© 2020 International Society of Blood Transfusion.

ID: 62050222