Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Free testosterone and cardiometabolic parameters in men: comparison of algorithms

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Cholecystokinin and the hormone concept

    Publikation: Bidrag til tidsskriftReviewpeer review

  2. Determining minimal important change for the thyroid-related quality of life questionnaire ThyPRO

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Plasma levels of glucagon but not GLP-1 are elevated in response to inflammation in humans

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The economic impact of prevention, monitoring and treatment strategies for iodine deficiency disorders in Germany

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The effects of selected inhibitors on human fetal adrenal steroidogenesis differs under basal and ACTH-stimulated conditions

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Cohort profile: The COPENHAGEN Minipuberty Study-A longitudinal prospective cohort of healthy full-term infants and their parents

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Variant PNLDC1, Defective piRNA Processing, and Azoospermia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Objective: Calculating the free testosterone level has gained increasing interest and different indirect algorithms have been suggested. The objective was to compare free androgen index (FAI), free testosterone estimated using the linear binding model (Vermeulen: cFTV) and the binding framework accounting for allosterically coupled SHBG monomers (Zakharov: cFTZ) in relation to cardiometabolic conditions.

Design: A prospective cohort study including 5350 men, aged 30-70 years, participating in population-based surveys (MONICA I-III and Inter99) from 1982 to 2001 and followed until December 2012 with baseline and follow-up information on cardiometabolic parameters and vital status.

Results: Using age-standardized hormone levels, FAI was higher among men with baseline cardiometabolic conditions, whereas cFTV and cFTZ levels were lower compared to men without these conditions as also seen for total testosterone. Men in highest quartiles of cFTV or cFTZ had lower risk of developing type 2 diabetes (cFTV: HR = 0.74 (0.49-1.10), cFTZ: HR = 0.59 (0.39-0.91)) than men in lowest quartile. In contrast, men with highest levels of FAI had a 74% (1.17-2.59) increased risk of developing type 2 diabetes compared to men in lowest quartile.

Conclusion: The association of estimated free testosterone and the studied outcomes differ depending on algorithm used. cFTV and cFTZ showed similar associations to baseline and long-term cardiometabolic parameters. In contrast, an empiric ratio, FAI, showed opposite associations to several of the examined parameters and may reflect limited clinical utility.

OriginalsprogEngelsk
TidsskriftEndocrine Connections
Vol/bind10
Udgave nummer2
Sider (fra-til)220-229
Antal sider10
ISSN2049-3614
DOI
StatusUdgivet - feb. 2021

ID: 63789382