Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Fracture risk in women with type II diabetes. Results from a historical cohort with fracture follow-up

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Interactions between hypothalamic pituitary thyroid axis and other pituitary dysfunctions

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. A randomized general population study of the effects of repeated health checks on incident diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Heterogeneity in glucose response curves during an oral glucose tolerance test and associated cardiometabolic risk

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Vitamin D and gallstone disease-A population-based study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Intensive screening for osteoporosis in patients with hip fracture

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Multiple Fractures and Impaired Bone Fracture Healing in a Patient with Pycnodysostosis and Hypophosphatasia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Low versus High Carbohydrate Diet in Type 1 Diabetes: A 12-week randomized open-label crossover study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Osteogenesis imperfecta and the teeth, eyes, and ears-a study of non-skeletal phenotypes in adults

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Dual energy X-ray kombineret med vertebral fracture assessment giver bedre diagnostik af osteporose

    Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Vis graf over relationer

PURPOSE: To examine the independent association between type II diabetes and fracture risk in a population of predominantly postmenopausal women referred to a specialist clinic for osteoporosis evaluation.

METHODS: Type II diabetes associated fracture risk were evaluated among to 229 patients with type II diabetes in a cohort of 6285 women followed on average (until major osteoporotic fracture (MOF), death or end of study) for 5.8 years. Information of fracture risk factors was obtained from a clinical database and from national registries.

RESULTS: An elevated fracture risk was present. Prevalent fractures (43.7 vs. 33.2%, p = 0.0010) and prevalent MOF (26.2 vs. 20.5% p = 0.038) were more common among patients with type II diabetes. The unadjusted incident fracture risk was increased with a higher relative risk of 42%. An elevated MOF hazard ratio was present (HR = 1.726, p = 0.0006). Adjustment for prevalent osteoporosis and other possible confounders did not change this finding (HR = 1.558, p = 0.0207).

CONCLUSIONS: An association between type II diabetes and an increased risk of MOF primarily driven by an increased hip fracture risk was documented. This finding was independent of the presence of osteoporosis. Clinicians need to be aware of and adjust for these findings when evaluating patients with diabetes. Additional research examining pathophysiological mechanisms are needed.

OriginalsprogEngelsk
TidsskriftEndocrine
Vol/bind60
Udgave nummer1
Sider (fra-til)151-158
ISSN1355-008X
DOI
StatusUdgivet - apr. 2018

ID: 52738218