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Fraction of exhaled nitric oxide levels are elevated in people living with HIV compared to uninfected controls suggesting increased eosinophilic airway inflammation

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@article{e2f72c597ae4435591e9ff83b00cb65b,
title = "Fraction of exhaled nitric oxide levels are elevated in people living with HIV compared to uninfected controls suggesting increased eosinophilic airway inflammation",
abstract = "OBJECTIVE: Increased risk of asthma and chronic obstructive pulmonary disease has been reported in people living with HIV (PLWH). Fraction of exhaled Nitric Oxide (FeNO) is a marker of eosinophilic airway inflammation. We assessed FeNO levels in PLWH and matched uninfected controls and investigated whether HIV status is independently associated with elevated FeNO.METHODS: FeNO was quantified by NIOX Vero{\circledR} and pulmonary function was assessed by spirometry in 432 PLWH from the Copenhagen Comorbidity in HIV Infection (COCOMO) Study and in 1618 age- and sex-matched uninfected controls from the Copenhagen General Population Study. Elevated FeNO was defined as ≥ 25 ppb. Associations between FeNO and HIV status were adjusted for known potential confounders.RESULTS: Mean age ± standard deviation (SD) of PLWH was 50.7 ± (11.1) years and 97.4{\%} received combination antiretroviral therapy. PLWH had higher FeNO than uninfected controls (median (IQR)) 17.0 (11.0-26.0) versus 13.0 (9.0-19.0), p<0.001. Also, PLWH had a higher prevalence of elevated FeNO than uninfected controls (27.5{\%} versus 12.3{\%}, p<0.001), (odds ratio (OR): 2.71 [95{\%}CI: 2.09-3.51], p<0.001). This association remained after adjusting for age, sex, height, smoking status, use of airway medication, blood eosinophils and IgE (adjusted OR (aOR): 3.56 [95{\%}CI: 2.51-5.04], p<0.001). Elevated FeNO was associated with an increased risk of self-reported asthma (aOR: 2.65 [95{\%}CI: 1.66-4.24], p<0.001) but not with airflow limitation (FEV1/FVCCONCLUSION: HIV status was independently associated with elevated FeNO suggesting increased eosinophilic airway inflammation. The potential impact on chronic lung disease pathogenesis needs further investigation.",
author = "Thudium, {Rebekka F} and Hughes, {Nicolai L P} and Shoaib Afzal and Yunus {\cC}olak and Marco Gelpi and Knudsen, {Andreas D} and Kirkegaard-Klitbo, {Ditte Marie} and Borges, {{\'A}lvaro H} and Jan Gerstoft and Nordestgaard, {B{\o}rge G} and J{\o}rgen Vestbo and Jens Lundgren and Andreas Ronit and Nielsen, {Susanne D}",
note = "{\circledC} The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2020",
month = "1",
day = "4",
doi = "10.1093/cid/ciz1223",
language = "English",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "University of Chicago Press",

}

RIS

TY - JOUR

T1 - Fraction of exhaled nitric oxide levels are elevated in people living with HIV compared to uninfected controls suggesting increased eosinophilic airway inflammation

AU - Thudium, Rebekka F

AU - Hughes, Nicolai L P

AU - Afzal, Shoaib

AU - Çolak, Yunus

AU - Gelpi, Marco

AU - Knudsen, Andreas D

AU - Kirkegaard-Klitbo, Ditte Marie

AU - Borges, Álvaro H

AU - Gerstoft, Jan

AU - Nordestgaard, Børge G

AU - Vestbo, Jørgen

AU - Lundgren, Jens

AU - Ronit, Andreas

AU - Nielsen, Susanne D

N1 - © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

PY - 2020/1/4

Y1 - 2020/1/4

N2 - OBJECTIVE: Increased risk of asthma and chronic obstructive pulmonary disease has been reported in people living with HIV (PLWH). Fraction of exhaled Nitric Oxide (FeNO) is a marker of eosinophilic airway inflammation. We assessed FeNO levels in PLWH and matched uninfected controls and investigated whether HIV status is independently associated with elevated FeNO.METHODS: FeNO was quantified by NIOX Vero® and pulmonary function was assessed by spirometry in 432 PLWH from the Copenhagen Comorbidity in HIV Infection (COCOMO) Study and in 1618 age- and sex-matched uninfected controls from the Copenhagen General Population Study. Elevated FeNO was defined as ≥ 25 ppb. Associations between FeNO and HIV status were adjusted for known potential confounders.RESULTS: Mean age ± standard deviation (SD) of PLWH was 50.7 ± (11.1) years and 97.4% received combination antiretroviral therapy. PLWH had higher FeNO than uninfected controls (median (IQR)) 17.0 (11.0-26.0) versus 13.0 (9.0-19.0), p<0.001. Also, PLWH had a higher prevalence of elevated FeNO than uninfected controls (27.5% versus 12.3%, p<0.001), (odds ratio (OR): 2.71 [95%CI: 2.09-3.51], p<0.001). This association remained after adjusting for age, sex, height, smoking status, use of airway medication, blood eosinophils and IgE (adjusted OR (aOR): 3.56 [95%CI: 2.51-5.04], p<0.001). Elevated FeNO was associated with an increased risk of self-reported asthma (aOR: 2.65 [95%CI: 1.66-4.24], p<0.001) but not with airflow limitation (FEV1/FVCCONCLUSION: HIV status was independently associated with elevated FeNO suggesting increased eosinophilic airway inflammation. The potential impact on chronic lung disease pathogenesis needs further investigation.

AB - OBJECTIVE: Increased risk of asthma and chronic obstructive pulmonary disease has been reported in people living with HIV (PLWH). Fraction of exhaled Nitric Oxide (FeNO) is a marker of eosinophilic airway inflammation. We assessed FeNO levels in PLWH and matched uninfected controls and investigated whether HIV status is independently associated with elevated FeNO.METHODS: FeNO was quantified by NIOX Vero® and pulmonary function was assessed by spirometry in 432 PLWH from the Copenhagen Comorbidity in HIV Infection (COCOMO) Study and in 1618 age- and sex-matched uninfected controls from the Copenhagen General Population Study. Elevated FeNO was defined as ≥ 25 ppb. Associations between FeNO and HIV status were adjusted for known potential confounders.RESULTS: Mean age ± standard deviation (SD) of PLWH was 50.7 ± (11.1) years and 97.4% received combination antiretroviral therapy. PLWH had higher FeNO than uninfected controls (median (IQR)) 17.0 (11.0-26.0) versus 13.0 (9.0-19.0), p<0.001. Also, PLWH had a higher prevalence of elevated FeNO than uninfected controls (27.5% versus 12.3%, p<0.001), (odds ratio (OR): 2.71 [95%CI: 2.09-3.51], p<0.001). This association remained after adjusting for age, sex, height, smoking status, use of airway medication, blood eosinophils and IgE (adjusted OR (aOR): 3.56 [95%CI: 2.51-5.04], p<0.001). Elevated FeNO was associated with an increased risk of self-reported asthma (aOR: 2.65 [95%CI: 1.66-4.24], p<0.001) but not with airflow limitation (FEV1/FVCCONCLUSION: HIV status was independently associated with elevated FeNO suggesting increased eosinophilic airway inflammation. The potential impact on chronic lung disease pathogenesis needs further investigation.

U2 - 10.1093/cid/ciz1223

DO - 10.1093/cid/ciz1223

M3 - Journal article

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

ER -

ID: 58903180