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Four-point impedance as a biomarker for bleeding during cochlear implantation

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Harvard

Bester, C, Razmovski, T, Collins, A, Mejia, O, Foghsgaard, S, Mitchell-Innes, A, Shaul, C, Campbell, L, Eastwood, H & O'Leary, S 2020, 'Four-point impedance as a biomarker for bleeding during cochlear implantation' Scientific Reports, bind 10, nr. 1, s. 2777. https://doi.org/10.1038/s41598-019-56253-w

APA

Bester, C., Razmovski, T., Collins, A., Mejia, O., Foghsgaard, S., Mitchell-Innes, A., ... O'Leary, S. (2020). Four-point impedance as a biomarker for bleeding during cochlear implantation. Scientific Reports, 10(1), 2777. https://doi.org/10.1038/s41598-019-56253-w

CBE

Bester C, Razmovski T, Collins A, Mejia O, Foghsgaard S, Mitchell-Innes A, Shaul C, Campbell L, Eastwood H, O'Leary S. 2020. Four-point impedance as a biomarker for bleeding during cochlear implantation. Scientific Reports. 10(1):2777. https://doi.org/10.1038/s41598-019-56253-w

MLA

Vancouver

Author

Bester, Christofer ; Razmovski, Tayla ; Collins, Aaron ; Mejia, Olivia ; Foghsgaard, Søren ; Mitchell-Innes, Alistair ; Shaul, Chanan ; Campbell, Luke ; Eastwood, Hayden ; O'Leary, Stephen. / Four-point impedance as a biomarker for bleeding during cochlear implantation. I: Scientific Reports. 2020 ; Bind 10, Nr. 1. s. 2777.

Bibtex

@article{2ffdcc2618c14f708e0d856798750d69,
title = "Four-point impedance as a biomarker for bleeding during cochlear implantation",
abstract = "Cochlear implantation has successfully restored the perception of hearing for nearly 200 thousand profoundly deaf adults and children. More recently, implant candidature has expanded to include those with considerable natural hearing which, when preserved, provides an improved hearing experience in noisy environments. But more than half of these patients lose this natural hearing soon after implantation. To reduce this burden, biosensing technologies are emerging that provide feedback on the quality of surgery. Here we report clinical findings on a new intra-operative measurement of electrical impedance (4-point impedance) which, when elevated, is associated with high rates of post-operative hearing loss and vestibular dysfunction. In vivo and in vitro data presented suggest that elevated 4-point impedance is likely due to the presence of blood within the cochlea rather than its geometry. Four-point impedance is a new marker for the detection of cochlear injury causing bleeding, that may be incorporated into intraoperative monitoring protocols during CI surgery.",
author = "Christofer Bester and Tayla Razmovski and Aaron Collins and Olivia Mejia and S{\o}ren Foghsgaard and Alistair Mitchell-Innes and Chanan Shaul and Luke Campbell and Hayden Eastwood and Stephen O'Leary",
year = "2020",
month = "2",
day = "17",
doi = "10.1038/s41598-019-56253-w",
language = "English",
volume = "10",
pages = "2777",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Four-point impedance as a biomarker for bleeding during cochlear implantation

AU - Bester, Christofer

AU - Razmovski, Tayla

AU - Collins, Aaron

AU - Mejia, Olivia

AU - Foghsgaard, Søren

AU - Mitchell-Innes, Alistair

AU - Shaul, Chanan

AU - Campbell, Luke

AU - Eastwood, Hayden

AU - O'Leary, Stephen

PY - 2020/2/17

Y1 - 2020/2/17

N2 - Cochlear implantation has successfully restored the perception of hearing for nearly 200 thousand profoundly deaf adults and children. More recently, implant candidature has expanded to include those with considerable natural hearing which, when preserved, provides an improved hearing experience in noisy environments. But more than half of these patients lose this natural hearing soon after implantation. To reduce this burden, biosensing technologies are emerging that provide feedback on the quality of surgery. Here we report clinical findings on a new intra-operative measurement of electrical impedance (4-point impedance) which, when elevated, is associated with high rates of post-operative hearing loss and vestibular dysfunction. In vivo and in vitro data presented suggest that elevated 4-point impedance is likely due to the presence of blood within the cochlea rather than its geometry. Four-point impedance is a new marker for the detection of cochlear injury causing bleeding, that may be incorporated into intraoperative monitoring protocols during CI surgery.

AB - Cochlear implantation has successfully restored the perception of hearing for nearly 200 thousand profoundly deaf adults and children. More recently, implant candidature has expanded to include those with considerable natural hearing which, when preserved, provides an improved hearing experience in noisy environments. But more than half of these patients lose this natural hearing soon after implantation. To reduce this burden, biosensing technologies are emerging that provide feedback on the quality of surgery. Here we report clinical findings on a new intra-operative measurement of electrical impedance (4-point impedance) which, when elevated, is associated with high rates of post-operative hearing loss and vestibular dysfunction. In vivo and in vitro data presented suggest that elevated 4-point impedance is likely due to the presence of blood within the cochlea rather than its geometry. Four-point impedance is a new marker for the detection of cochlear injury causing bleeding, that may be incorporated into intraoperative monitoring protocols during CI surgery.

U2 - 10.1038/s41598-019-56253-w

DO - 10.1038/s41598-019-56253-w

M3 - Journal article

VL - 10

SP - 2777

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

ER -

ID: 60286655