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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Forøget renal udskillelse af antibiotika kan resultere i underdosering ved sepsis

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Vis graf over relationer

Early, relevant antibiotic treatment is of pivotal significance for survival for patients with sepsis. Recent reports reveal, that critically ill patients may need substantially higher dosing of antibiotics than the usual standards. The background is the newly described augmented renal clearance (ARC), which can be observed in critically ill patients with sepsis. ARC results in significantly reduced antibiotic concentrations in patients with sepsis and can potentially have fatal consequences. The purpose of this paper is to make medical doctors aware of the phenomenon and to compensate for the increased antibiotic clearance.

Bidragets oversatte titelAugmented renal clearance of antibiotics may lead to inadequate dosings for patients with sepsis
OriginalsprogDansk
TidsskriftUgeskrift for Laeger
Vol/bind178
Udgave nummer11
Sider (fra-til)V05150426
ISSN0041-5782
StatusUdgivet - 14 mar. 2016

ID: 49908746