Forekomst af testikelkraeft hos maend med nedsat fertilitet. En case-control undersøgelse

H Møller, N E Skakkebaek

Abstract

In order to evaluate the association between male subfertility and the subsequent risk of testicular cancer, a population-based case-control study was conducted in The Danish population. Cases were identified in the Danish Cancer Registry; controls were randomly selected from the Danish population using the computerized Danish Central Population Register. The men were interviewed by telephone; 514 cases and 720 controls participated. A reduced risk of testicular cancer was associated with paternity (relative risk = 0.63; 95% confidence interval: 0.47-0.85). In men who prior to the diagnosis of testicular cancer had a lower number of children than expected on the basis of their age, the relative risk was 1.98 (95% confidence interval: 1.43-2.75). There was no corresponding protective effect associated with a higher number of children than expected. The associations were similar for seminoma and non-seminoma, and were not influenced by adjustment for potential confounding factors. These data are consistent with the hypothesis that male subfertility and testicular cancer share important aetiological factors.

Bidragets oversatte titelOccurrence of testicular cancer in subfertile men. A case-control study
OriginalsprogDansk
TidsskriftUgeskrift for Laeger
Vol/bind161
Udgave nummer47
Sider (fra-til)6490-2
Antal sider3
ISSN0041-5782
StatusUdgivet - 22 nov. 1999
Udgivet eksterntJa

Emneord

  • Adult
  • Aged
  • Case-Control Studies
  • Denmark/epidemiology
  • Humans
  • Infertility, Male/complications
  • Male
  • Middle Aged
  • Registries
  • Risk Factors
  • Surveys and Questionnaires
  • Testicular Neoplasms/epidemiology

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