TY - JOUR
T1 - Forebyggelse af skeletrelaterede hændelser hos patienter med knoglemetastaser ved solide tumorer
AU - Kamby, Claus
AU - Tarp, Simon
AU - Mellemgaard, Anders
AU - Christensen, Robin
AU - Cold, Søren
AU - Eiken, Pia
AU - Jakobsen, Erik Hugger
AU - Langkilde, Niels Christian
AU - Langkjer, Sven Tyge
AU - Laursen, Torben
AU - Ottesen, Svend Saalbach
AU - Pedersen, Anita Gorm
AU - Stenbygaard, Lars Eric
AU - Vestlev, Peter Michael
PY - 2015
Y1 - 2015
N2 - This article is based on a systematic literature search and meta-analyses of clinical data regarding effects of bisphosphonates (BP) and denosumab (DS) on preventing skeletal related events (SRE) in patients with bone metastases from solid tumours. Although there are pharmacological differences between the different types of BP no major differences were observed between BP in preventing SRE or in adverse events. Treatment with DS has in three randomised trials showed a greater effect than BP in preventing SRE. The optimal choice of bone-anti-resorptive agent should depend on the patient's general condition, renal function and treatment logistics.
AB - This article is based on a systematic literature search and meta-analyses of clinical data regarding effects of bisphosphonates (BP) and denosumab (DS) on preventing skeletal related events (SRE) in patients with bone metastases from solid tumours. Although there are pharmacological differences between the different types of BP no major differences were observed between BP in preventing SRE or in adverse events. Treatment with DS has in three randomised trials showed a greater effect than BP in preventing SRE. The optimal choice of bone-anti-resorptive agent should depend on the patient's general condition, renal function and treatment logistics.
M3 - Tidsskriftartikel
C2 - 25350304
SN - 1603-6824
VL - 177
SP - 645
EP - 648
JO - Ugeskrift for læger [online]
JF - Ugeskrift for læger [online]
IS - 7
ER -