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Forearm metabolism during infusion of adrenaline: comparison of the dominant and non-dominant arm

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@article{78b967a962084a1386cfbfdc1334dd96,
title = "Forearm metabolism during infusion of adrenaline: comparison of the dominant and non-dominant arm",
abstract = "Human skeletal muscle metabolism is often investigated by measurements of substrate fluxes across the forearm. To evaluate whether the two forearms give the same metabolic information, nine healthy subjects were studied in the fasted state and during infusion of adrenaline. Both arms were catheterized in a cubital vein in the retrograde direction. A femoral artery was catheterized for blood sampling, and a femoral vein for infusion of adrenaline. Forearm blood flow was measured by venous occlusion strain-gauge plethysmography. Forearm subcutaneous adipose tissue blood flow was measured by the local 133Xe washout method. Metabolic fluxes were calculated as the product of forearm blood flow and a-v differences of metabolite concentrations. After baseline measurements, adrenaline was infused at a rate of 0.3 nmol kg-1 min-1. No difference in the metabolic information obtained in the fasting state could be demonstrated. During infusion of adrenaline, blood flow and lactate output increased significantly more in the non-dominant arm (8.12 +/- 1.24 versus 6.45 +/- 1.19 ml 100 g-1 min-1) and (2.99 +/- 0.60 versus 1.83 +/- 0.43 micromol 100 g-1 min-1). Adrenaline induced a significant increase in oxygen uptake in the non-dominant forearm (baseline period: 4.98 +/- 0.72 micromol 100 g-1 min-1; adrenaline period: 6.63 +/- 0.62 micromol 100 g-1 min-1) while there was no increase in the dominant forearm (baseline period: 5.69 +/- 1.03 micromol 100 g-1 min-1; adrenaline period: 4. 94 +/- 0.84 micromol 100 g-1 min-1). It is concluded that the two forearms do not respond equally to adrenaline stimulation. Thus, when comparing results from different studies, it is necessary to know which arm was examined.",
keywords = "Adipose Tissue, Adult, Epinephrine, Fasting, Female, Forearm, Functional Laterality, Humans, Lactic Acid, Male, Muscle, Skeletal, Oxygen Consumption, Regional Blood Flow, Vasoconstrictor Agents",
author = "L Simonsen and B Stefl and J B{\"u}low",
year = "2000",
month = jan,
language = "English",
volume = "20",
pages = "8--13",
journal = "Clinical Physiology",
issn = "0144-5979",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Forearm metabolism during infusion of adrenaline

T2 - comparison of the dominant and non-dominant arm

AU - Simonsen, L

AU - Stefl, B

AU - Bülow, J

PY - 2000/1

Y1 - 2000/1

N2 - Human skeletal muscle metabolism is often investigated by measurements of substrate fluxes across the forearm. To evaluate whether the two forearms give the same metabolic information, nine healthy subjects were studied in the fasted state and during infusion of adrenaline. Both arms were catheterized in a cubital vein in the retrograde direction. A femoral artery was catheterized for blood sampling, and a femoral vein for infusion of adrenaline. Forearm blood flow was measured by venous occlusion strain-gauge plethysmography. Forearm subcutaneous adipose tissue blood flow was measured by the local 133Xe washout method. Metabolic fluxes were calculated as the product of forearm blood flow and a-v differences of metabolite concentrations. After baseline measurements, adrenaline was infused at a rate of 0.3 nmol kg-1 min-1. No difference in the metabolic information obtained in the fasting state could be demonstrated. During infusion of adrenaline, blood flow and lactate output increased significantly more in the non-dominant arm (8.12 +/- 1.24 versus 6.45 +/- 1.19 ml 100 g-1 min-1) and (2.99 +/- 0.60 versus 1.83 +/- 0.43 micromol 100 g-1 min-1). Adrenaline induced a significant increase in oxygen uptake in the non-dominant forearm (baseline period: 4.98 +/- 0.72 micromol 100 g-1 min-1; adrenaline period: 6.63 +/- 0.62 micromol 100 g-1 min-1) while there was no increase in the dominant forearm (baseline period: 5.69 +/- 1.03 micromol 100 g-1 min-1; adrenaline period: 4. 94 +/- 0.84 micromol 100 g-1 min-1). It is concluded that the two forearms do not respond equally to adrenaline stimulation. Thus, when comparing results from different studies, it is necessary to know which arm was examined.

AB - Human skeletal muscle metabolism is often investigated by measurements of substrate fluxes across the forearm. To evaluate whether the two forearms give the same metabolic information, nine healthy subjects were studied in the fasted state and during infusion of adrenaline. Both arms were catheterized in a cubital vein in the retrograde direction. A femoral artery was catheterized for blood sampling, and a femoral vein for infusion of adrenaline. Forearm blood flow was measured by venous occlusion strain-gauge plethysmography. Forearm subcutaneous adipose tissue blood flow was measured by the local 133Xe washout method. Metabolic fluxes were calculated as the product of forearm blood flow and a-v differences of metabolite concentrations. After baseline measurements, adrenaline was infused at a rate of 0.3 nmol kg-1 min-1. No difference in the metabolic information obtained in the fasting state could be demonstrated. During infusion of adrenaline, blood flow and lactate output increased significantly more in the non-dominant arm (8.12 +/- 1.24 versus 6.45 +/- 1.19 ml 100 g-1 min-1) and (2.99 +/- 0.60 versus 1.83 +/- 0.43 micromol 100 g-1 min-1). Adrenaline induced a significant increase in oxygen uptake in the non-dominant forearm (baseline period: 4.98 +/- 0.72 micromol 100 g-1 min-1; adrenaline period: 6.63 +/- 0.62 micromol 100 g-1 min-1) while there was no increase in the dominant forearm (baseline period: 5.69 +/- 1.03 micromol 100 g-1 min-1; adrenaline period: 4. 94 +/- 0.84 micromol 100 g-1 min-1). It is concluded that the two forearms do not respond equally to adrenaline stimulation. Thus, when comparing results from different studies, it is necessary to know which arm was examined.

KW - Adipose Tissue

KW - Adult

KW - Epinephrine

KW - Fasting

KW - Female

KW - Forearm

KW - Functional Laterality

KW - Humans

KW - Lactic Acid

KW - Male

KW - Muscle, Skeletal

KW - Oxygen Consumption

KW - Regional Blood Flow

KW - Vasoconstrictor Agents

M3 - Journal article

C2 - 10651786

VL - 20

SP - 8

EP - 13

JO - Clinical Physiology

JF - Clinical Physiology

SN - 0144-5979

IS - 1

ER -

ID: 39021731