Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Forced fluid removal in intensive care patients with acute kidney injury: The randomised FFAKI feasibility trial

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. A marking of the cricothyroid membrane with extended neck returns to correct position after neck manipulation and repositioning

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Association between transfusion of blood products and acute kidney injury following cardiac surgery

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Ketamine for rapid sequence intubation in adult trauma patients: A retrospective observational study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia (COVID STEROID) trial-Protocol and statistical analysis plan

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Lactate versus acetate buffered intravenous crystalloid solutions: a scoping review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Evaluating Non-Statistically Significant Results From Trials in Practice-Reply

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

Vis graf over relationer

BACKGROUND: Accumulation of fluids is frequent in intensive care unit (ICU) patients with acute kidney injury and may be associated with increased mortality and decreased renal recovery. We present the results of a pilot trial assessing the feasibility of forced fluid removal in ICU patients with acute kidney injury and fluid accumulation of more than 10% ideal bodyweight.

METHODS: The FFAKI-trial was a pilot trial of forced fluid removal vs standard care in adult ICU patients with moderate to high risk acute kidney injury and 10% fluid accumulation. Fluid removal was done with furosemide and/or continuous renal replacement therapy aiming at net negative fluid balance > 1 mL/kg ideal body weight/hour until cumulative fluid balance calculated from ICU admission reached less than 1000 mL.

RESULTS: After 20 months, we stopped the trial prematurely due to a low inclusion rate with 23 (2%) included patients out of the 1144 screened. Despite the reduced sample size, we observed a marked reduction in cumulative fluid balance 5 days after randomisation (mean difference -5814 mL, 95% CI -2063 to -9565, P = .003) with forced fluid removal compared to standard care. While the trial was underpowered for clinical endpoints, no point estimates suggested harm from forced fluid removal.

CONCLUSIONS: Forced fluid removal aiming at 1 mL/kg ideal body weight/hour may be an effective treatment of fluid accumulation in ICU patients with acute kidney injury. A definitive trial using our inclusion criteria seems less feasible based on our inclusion rate of only 2%.

OriginalsprogEngelsk
TidsskriftActa Anaesthesiologica Scandinavica
Vol/bind62
Udgave nummer7
Sider (fra-til)936-944
ISSN0001-5172
DOI
StatusUdgivet - 2018

ID: 54449404