Harvard
Rasmussen, PK, Ralfkiaer, E, Prause, JU, Sjö, LD, Specht, L, Rossing, HH, Siersma, VD
& Heegaard, S 2015, '
Follicular lymphoma of the ocular adnexal region: A nation-based study'
Acta Ophthalmologica, bind 93, nr. 2, s. 184-91.
https://doi.org/10.1111/aos.12525
APA
Rasmussen, P. K., Ralfkiaer, E., Prause, J. U., Sjö, L. D., Specht, L., Rossing, H. H., ... Heegaard, S. (2015).
Follicular lymphoma of the ocular adnexal region: A nation-based study.
Acta Ophthalmologica,
93(2), 184-91.
https://doi.org/10.1111/aos.12525
CBE
MLA
Vancouver
Author
Bibtex
@article{c65257c6fadb4ad5a669eaf5f1b18c1f,
title = "Follicular lymphoma of the ocular adnexal region: A nation-based study",
abstract = "PURPOSE: To characterize the clinicopathological features of follicular lymphoma of the ocular adnexal region.METHODS: Retrospective nation-based study of Danish patients with ocular adnexal follicular lymphoma from January 1st 1980 through December 31st 2009.RESULTS: Twenty-four patients with ocular adnexal follicular lymphoma were identified. Fourteen (58{\%}) of the patients were females. The median age was 63 years (range: 42-96 years). Eleven (46{\%}) of the patients had primary ocular adnexal lymphoma, seven (29{\%}) had an ocular adnexal lesion in conjunction with a concurrent systemic lymphoma and six patients (25{\%}) presented with an ocular adnexal relapse. The most frequently affected sites were the lacrimal gland (38{\%}) and the orbit (33{\%}). Thirteen patients (54{\%}) presented with Ann Arbor stage IE lymphoma, four (17{\%}) had stage IIE, two patients (8{\%}) stage IIIE, and five patients (21{\%}) had stage IV lymphoma. Radiotherapy was primarily used in patients with primary lymphoma and those with a stage IE/IIE relapse (82{\%}), while stage IIIE/IV lymphomas most frequently received alkylating chemotherapy (67{\%}). Complete remission was observed in 19 of the patients (79{\%}), but of these 11(58{\%}) had a relapse. The 10-year overall survival for the entire cohort was 59{\%}. The translocation t(14;18) was detected in 16 patients (16/24, 76{\%}). Recurrence was only observed in patients with the t(14;18) (p = 0.05, log-rank).CONCLUSIONS: Ocular adnexal follicular lymphoma is more commonly found in elderly female patients. The lacrimal gland is relatively frequently involved. Radiotherapy is the treatment of choice for localized ocular adnexal follicular lymphoma providing a favourable prognosis for majority of patients.",
author = "Rasmussen, {Peter K} and Elisabeth Ralfkiaer and Prause, {Jan U.} and Sj{\"o}, {Lene D} and Lena Specht and Rossing, {Henrik H} and Siersma, {Volkert D} and Steffen Heegaard",
note = "{\circledC} 2014 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.",
year = "2015",
doi = "10.1111/aos.12525",
language = "English",
volume = "93",
pages = "184--91",
journal = "Acta Ophthalmologica",
issn = "1755-375X",
publisher = "Wiley-Blackwell Munksgaard",
number = "2",
}
RIS
TY - JOUR
T1 - Follicular lymphoma of the ocular adnexal region
T2 - A nation-based study
AU - Rasmussen, Peter K
AU - Ralfkiaer, Elisabeth
AU - Prause, Jan U.
AU - Sjö, Lene D
AU - Specht, Lena
AU - Rossing, Henrik H
AU - Siersma, Volkert D
AU - Heegaard, Steffen
N1 - © 2014 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.
PY - 2015
Y1 - 2015
N2 - PURPOSE: To characterize the clinicopathological features of follicular lymphoma of the ocular adnexal region.METHODS: Retrospective nation-based study of Danish patients with ocular adnexal follicular lymphoma from January 1st 1980 through December 31st 2009.RESULTS: Twenty-four patients with ocular adnexal follicular lymphoma were identified. Fourteen (58%) of the patients were females. The median age was 63 years (range: 42-96 years). Eleven (46%) of the patients had primary ocular adnexal lymphoma, seven (29%) had an ocular adnexal lesion in conjunction with a concurrent systemic lymphoma and six patients (25%) presented with an ocular adnexal relapse. The most frequently affected sites were the lacrimal gland (38%) and the orbit (33%). Thirteen patients (54%) presented with Ann Arbor stage IE lymphoma, four (17%) had stage IIE, two patients (8%) stage IIIE, and five patients (21%) had stage IV lymphoma. Radiotherapy was primarily used in patients with primary lymphoma and those with a stage IE/IIE relapse (82%), while stage IIIE/IV lymphomas most frequently received alkylating chemotherapy (67%). Complete remission was observed in 19 of the patients (79%), but of these 11(58%) had a relapse. The 10-year overall survival for the entire cohort was 59%. The translocation t(14;18) was detected in 16 patients (16/24, 76%). Recurrence was only observed in patients with the t(14;18) (p = 0.05, log-rank).CONCLUSIONS: Ocular adnexal follicular lymphoma is more commonly found in elderly female patients. The lacrimal gland is relatively frequently involved. Radiotherapy is the treatment of choice for localized ocular adnexal follicular lymphoma providing a favourable prognosis for majority of patients.
AB - PURPOSE: To characterize the clinicopathological features of follicular lymphoma of the ocular adnexal region.METHODS: Retrospective nation-based study of Danish patients with ocular adnexal follicular lymphoma from January 1st 1980 through December 31st 2009.RESULTS: Twenty-four patients with ocular adnexal follicular lymphoma were identified. Fourteen (58%) of the patients were females. The median age was 63 years (range: 42-96 years). Eleven (46%) of the patients had primary ocular adnexal lymphoma, seven (29%) had an ocular adnexal lesion in conjunction with a concurrent systemic lymphoma and six patients (25%) presented with an ocular adnexal relapse. The most frequently affected sites were the lacrimal gland (38%) and the orbit (33%). Thirteen patients (54%) presented with Ann Arbor stage IE lymphoma, four (17%) had stage IIE, two patients (8%) stage IIIE, and five patients (21%) had stage IV lymphoma. Radiotherapy was primarily used in patients with primary lymphoma and those with a stage IE/IIE relapse (82%), while stage IIIE/IV lymphomas most frequently received alkylating chemotherapy (67%). Complete remission was observed in 19 of the patients (79%), but of these 11(58%) had a relapse. The 10-year overall survival for the entire cohort was 59%. The translocation t(14;18) was detected in 16 patients (16/24, 76%). Recurrence was only observed in patients with the t(14;18) (p = 0.05, log-rank).CONCLUSIONS: Ocular adnexal follicular lymphoma is more commonly found in elderly female patients. The lacrimal gland is relatively frequently involved. Radiotherapy is the treatment of choice for localized ocular adnexal follicular lymphoma providing a favourable prognosis for majority of patients.
U2 - 10.1111/aos.12525
DO - 10.1111/aos.12525
M3 - Journal article
VL - 93
SP - 184
EP - 191
JO - Acta Ophthalmologica
JF - Acta Ophthalmologica
SN - 1755-375X
IS - 2
ER -