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Focal Epithelial Hyperplasia

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@article{a8225323f7154c05ab5f17b89fa759b4,
title = "Focal Epithelial Hyperplasia",
abstract = "Focal epithelial hyperplasia (FEH) or Heck's disease is a rare, benign, oral condition that is associated with infection by human papillomavirus type 13, 32 or both. The whiteish to mucosal-colored, soft, papular or nodular elevated lesions in the oral cavity are normally asymptomatic but can grow to a size or at a location where treatment is needed. The diagnosis is often based on clinical presentation and histopathology, and the HPV genotype can be determined using PCR utilizing specific primers or DNA sequencing. While FEH was reported to often affect several members of the same family and exist primarily among indigenous populations around the world, the number of reported cases within the European region is increasing. This contemporary review summarizes the main findings in relation to HPV genotypes, impact of superinfection exclusion and vaccination, transmission, diagnosis, geographical and ethnical distribution, comorbidities and treatment of FEH with an emphasis on including the most recent case reports within the field. Furthermore, we describe for the first time a FEH lesion infected with the low-risk HPV90.",
author = "Bendtsen, {Simone Kloch} and Jakobsen, {Kathrine Kronberg} and Carlander, {Amanda-Louise Fenger} and Christian Gr{\o}nh{\o}j and {von Buchwald}, Christian",
year = "2021",
month = aug,
day = "2",
doi = "10.3390/v13081529",
language = "English",
volume = "13",
journal = "Viruses-Basel",
issn = "1999-4915",
publisher = "M D P I AG",
number = "8",

}

RIS

TY - JOUR

T1 - Focal Epithelial Hyperplasia

AU - Bendtsen, Simone Kloch

AU - Jakobsen, Kathrine Kronberg

AU - Carlander, Amanda-Louise Fenger

AU - Grønhøj, Christian

AU - von Buchwald, Christian

PY - 2021/8/2

Y1 - 2021/8/2

N2 - Focal epithelial hyperplasia (FEH) or Heck's disease is a rare, benign, oral condition that is associated with infection by human papillomavirus type 13, 32 or both. The whiteish to mucosal-colored, soft, papular or nodular elevated lesions in the oral cavity are normally asymptomatic but can grow to a size or at a location where treatment is needed. The diagnosis is often based on clinical presentation and histopathology, and the HPV genotype can be determined using PCR utilizing specific primers or DNA sequencing. While FEH was reported to often affect several members of the same family and exist primarily among indigenous populations around the world, the number of reported cases within the European region is increasing. This contemporary review summarizes the main findings in relation to HPV genotypes, impact of superinfection exclusion and vaccination, transmission, diagnosis, geographical and ethnical distribution, comorbidities and treatment of FEH with an emphasis on including the most recent case reports within the field. Furthermore, we describe for the first time a FEH lesion infected with the low-risk HPV90.

AB - Focal epithelial hyperplasia (FEH) or Heck's disease is a rare, benign, oral condition that is associated with infection by human papillomavirus type 13, 32 or both. The whiteish to mucosal-colored, soft, papular or nodular elevated lesions in the oral cavity are normally asymptomatic but can grow to a size or at a location where treatment is needed. The diagnosis is often based on clinical presentation and histopathology, and the HPV genotype can be determined using PCR utilizing specific primers or DNA sequencing. While FEH was reported to often affect several members of the same family and exist primarily among indigenous populations around the world, the number of reported cases within the European region is increasing. This contemporary review summarizes the main findings in relation to HPV genotypes, impact of superinfection exclusion and vaccination, transmission, diagnosis, geographical and ethnical distribution, comorbidities and treatment of FEH with an emphasis on including the most recent case reports within the field. Furthermore, we describe for the first time a FEH lesion infected with the low-risk HPV90.

U2 - 10.3390/v13081529

DO - 10.3390/v13081529

M3 - Journal article

C2 - 34452393

VL - 13

JO - Viruses-Basel

JF - Viruses-Basel

SN - 1999-4915

IS - 8

ER -

ID: 67741542