Fluorine-18 labeled aldehydes as prosthetic groups for oxime coupling with a FVIIa protein

Troels E Jeppesen, Jesper B Kristensen, Carsten Behrens, Jacob Madsen, Andreas Kjaer

Abstract

New 18 F-labeled nonvolatile aldehyde prosthetic groups derived from [18 F]F-Py-TFP and spirocyclic iodonium (III)ylide precursors for late stage 18 F-labeling were developed. These precursors were characterized, 18 F-labeled, and compared in reactivity for oxime coupling. Oxime coupling was performed on an amino-oxy modified inhibited factor VII (FVIIai-ONH2 ) in low concentration to prove the applicability of the proposed method.

OriginalsprogEngelsk
TidsskriftJournal of Labelled Compounds and Radiopharmaceuticals
Vol/bind64
Udgave nummer5
Sider (fra-til)198-208
Antal sider11
ISSN0362-4803
DOI
StatusUdgivet - 15 maj 2021

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