Fluorine-18 labeled aldehydes as prosthetic groups for oxime coupling with a FVIIa protein

Troels E Jeppesen; Jesper B Kristensen; Carsten Behrens; Jacob Madsen; Andreas Kjaer

doi:10.1002/jlcr.3900

Fluorine-18 labeled aldehydes as prosthetic groups for oxime coupling with a FVIIa protein

Troels E Jeppesen, Jesper B Kristensen, Carsten Behrens, Jacob Madsen, Andreas Kjaer

Afdeling for Klinisk Fysiologi og Nuklearmedicin

Abstrakt

New 18 F-labeled nonvolatile aldehyde prosthetic groups derived from [18 F]F-Py-TFP and spirocyclic iodonium (III)ylide precursors for late stage 18 F-labeling were developed. These precursors were characterized, 18 F-labeled, and compared in reactivity for oxime coupling. Oxime coupling was performed on an amino-oxy modified inhibited factor VII (FVIIai-ONH2 ) in low concentration to prove the applicability of the proposed method.

Originalsprog	Engelsk
Tidsskrift	Journal of Labelled Compounds and Radiopharmaceuticals
Vol/bind	64
Udgave nummer	5
Sider (fra-til)	198-208
Antal sider	11
ISSN	0362-4803
DOI	https://doi.org/10.1002/jlcr.3900
Status	Udgivet - 15 maj 2021

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10.1002/jlcr.3900

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title = "Fluorine-18 labeled aldehydes as prosthetic groups for oxime coupling with a FVIIa protein",

abstract = "New 18 F-labeled nonvolatile aldehyde prosthetic groups derived from [18 F]F-Py-TFP and spirocyclic iodonium (III)ylide precursors for late stage 18 F-labeling were developed. These precursors were characterized, 18 F-labeled, and compared in reactivity for oxime coupling. Oxime coupling was performed on an amino-oxy modified inhibited factor VII (FVIIai-ONH2 ) in low concentration to prove the applicability of the proposed method.",

keywords = "Oximes",

author = "Jeppesen, {Troels E} and Kristensen, {Jesper B} and Carsten Behrens and Jacob Madsen and Andreas Kjaer",

note = "{\textcopyright} 2020 John Wiley & Sons, Ltd.",

year = "2021",

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language = "English",

volume = "64",

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journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

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TY - JOUR

T1 - Fluorine-18 labeled aldehydes as prosthetic groups for oxime coupling with a FVIIa protein

AU - Jeppesen, Troels E

AU - Kristensen, Jesper B

AU - Behrens, Carsten

AU - Madsen, Jacob

AU - Kjaer, Andreas

PY - 2021/5/15

Y1 - 2021/5/15

N2 - New 18 F-labeled nonvolatile aldehyde prosthetic groups derived from [18 F]F-Py-TFP and spirocyclic iodonium (III)ylide precursors for late stage 18 F-labeling were developed. These precursors were characterized, 18 F-labeled, and compared in reactivity for oxime coupling. Oxime coupling was performed on an amino-oxy modified inhibited factor VII (FVIIai-ONH2 ) in low concentration to prove the applicability of the proposed method.

AB - New 18 F-labeled nonvolatile aldehyde prosthetic groups derived from [18 F]F-Py-TFP and spirocyclic iodonium (III)ylide precursors for late stage 18 F-labeling were developed. These precursors were characterized, 18 F-labeled, and compared in reactivity for oxime coupling. Oxime coupling was performed on an amino-oxy modified inhibited factor VII (FVIIai-ONH2 ) in low concentration to prove the applicability of the proposed method.

KW - Oximes

UR - http://www.scopus.com/inward/record.url?scp=85099984260&partnerID=8YFLogxK

U2 - 10.1002/jlcr.3900

DO - 10.1002/jlcr.3900

M3 - Journal article

C2 - 33314295

VL - 64

SP - 198

EP - 208

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

SN - 0362-4803

IS - 5

ER -

Fluorine-18 labeled aldehydes as prosthetic groups for oxime coupling with a FVIIa protein

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