Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Flow-associated dilatory capacity of the brachial artery is intact in early autosomal dominant polycystic kidney disease

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Effect of the incretin hormones on the endocrine pancreas in end-stage renal disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Gastrointestinal motility in patients with end-stage renal disease on chronic hemodialysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Nyresygdomme

    Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiFormidling

Vis graf over relationer

BACKGROUND/AIMS: Autosomal dominant polycystic kidney disease is associated with endothelial dysfunction of resistance arteries. This study tested whether endothelial dysfunction is also present in the conduit arteries in patients with preserved renal function.

METHODS: Twenty-seven patients (9 females and 18 males, age 36 +/- 10 years) with polycystic kidney disease and normal renal function were compared to 27 healthy controls. The dilatory responses of the brachial artery to postischemic increased blood flow [endothelium-dependent flow-associated dilatation (FAD)] and to nitroglycerin [endothelium-independent nitroglycerin-induced dilatation (NID)] were measured by external ultrasound. Plasma concentrations of the stable end products of nitric oxide nitrate/nitrite (NOx) and of the endothelial markers vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1, E-selectin and von Willebrand factor antigen were also measured.

RESULTS: No differences in FAD or NID were found between patients and controls (104.6 +/- 4.2 vs. 105.3 +/- 3.9%, mean +/- SD, p = 0.55, and 117.0 +/- 8.4 vs. 117.5 +/- 7.6%, p = 0.75). However, the plasma concentration of VCAM-1 was elevated and the plasma concentration of NOx was reduced in patients with polycystic kidney disease.

CONCLUSION: Biochemical markers confirm an association between polycystic kidney disease and endothelial dysfunction. However, a normal FAD of the brachial artery suggests that the endothelial dysfunction does not involve the conduit arteries.

TidsskriftAmerican Journal of Nephrology
Udgave nummer4
Sider (fra-til)335-9
Antal sider5
StatusUdgivet - 2006

ID: 44874331