@article{da1c859b41bd4532aaae9a33fe05d6fb,
title = "Flow-mediated dilatation has no independent prognostic effect in patients with chest pain with or without ischaemic heart disease",
abstract = "OBJECTIVE: The purpose of this study was to assess the prognostic effect of flow-mediated dilatation (FMD) in patients with chest pain admitted to a coronary care unit. METHODS: Endothelium-dependent FMD in the brachial artery was examined in 223 patients with acute chest pain. All patients underwent a stress test at the time of admittance. On the basis of a positive stress test, a prior myocardial infarction (MI), prior percutaneous coronary intervention (PCI) or coronary bypass surgery (CABG), 137 patients were categorized as having ischaemic heart disease (IHD). RESULTS: Patients with IHD had significantly lower FMD than patients without IHD (p=0.002). During a mean follow-up of 4.2 years, 90 patients had an endpoint event, i.e. cardiovascular death, acute MI, unstable angina pectoris, PCI or CABG. In univariate analysis, FMD <3 % was associated with an increased hazard of the combined endpoint (p=0.04). In multivariate analysis, adjusted for age, gender, IHD and body mass index, no association between FMD and the combined endpoint was found (p=0.99). CONCLUSION: FMD is associated with IHD, but has no independent prognostic effect in patients with chest pain.",
keywords = "Adult, Chest Pain, Dilatation, Pathologic, Female, Humans, Male, Middle Aged, Myocardial Ischemia, Prognosis, Prospective Studies",
author = "Ulriksen, {Line Skjold} and Malmqvist, {Beata B} and Are Hansen and Jens Friberg and Jensen, {Gorm B}",
year = "2009",
doi = "10.1080/00365510902745378",
language = "English",
volume = "69",
pages = "475--80",
journal = "Scandinavian Journal of Clinical & Laboratory Investigation",
issn = "0036-5513",
publisher = "Informa Healthcare",
number = "4",
}