@article{459b20b5268f4590b2bd4ddf575a3e84,
title = "Flow cytometric analysis of cerebrospinal fluid improves detection of leukaemic blasts in infants with acute lymphoblastic leukaemia",
abstract = "Infants with acute lymphoblastic leukaemia (ALL) have a high frequency of central nervous system (CNS) involvement. Flow cytometric analysis of cerebrospinal fluid (CSF) was recently demonstrated to be a sensitive method for detecting CNS involvement in childhood ALL. In the present study, CSF from 14 infants was collected at routine lumbar punctures and analysed by multicolour flow cytometry. At initial diagnosis, leukaemic blasts were detected in CSF by flow cytometry in 11 patients (78·6%) compared to seven patients (50%) by cytospin. Larger studies are needed to determine if CSF flow cytometry has prognostic value in infant ALL.",
keywords = "Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Cerebrospinal Fluid/cytology, Female, Flow Cytometry/methods, Follow-Up Studies, Humans, Infant, Infant, Newborn, Leukemic Infiltration/diagnosis, Male, Neoplastic Stem Cells/pathology, Precursor Cell Lymphoblastic Leukemia-Lymphoma/cerebrospinal fluid, Recurrence",
author = "Maria Thastrup and Marquart, {Hanne Vibeke} and Mette Levinsen and Signe Modvig and Jonas Abrahamsson and Albertsen, {Birgitte Klug} and Britt-Marie Frost and Arja Harila-Saari and Jouni Pesola and Aina Ulvmoen and Wojcik, {Dorota Malgorzata} and Mervi Taskinen and Marianne Hoffmann and Birgitte Lausen and Kjeld Schmiegelow and {Nordic Society of Paediatric Haematology, Oncology (NOPHO)}",
note = "{\textcopyright} 2021 British Society for Haematology and John Wiley & Sons Ltd.",
year = "2021",
month = oct,
doi = "10.1111/bjh.17769",
language = "English",
volume = "195",
pages = "119--122",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "John Wiley and Sons Inc.",
number = "1",
}