Flow cytometric analysis of cerebrospinal fluid improves detection of leukaemic blasts in infants with acute lymphoblastic leukaemia

Maria Thastrup, Hanne Vibeke Marquart, Mette Levinsen, Signe Modvig, Jonas Abrahamsson, Birgitte Klug Albertsen, Britt-Marie Frost, Arja Harila-Saari, Jouni Pesola, Aina Ulvmoen, Dorota Malgorzata Wojcik, Mervi Taskinen, Marianne Hoffmann, Birgitte Lausen, Kjeld Schmiegelow, Nordic Society of Paediatric Haematology, Oncology (NOPHO)

Abstract

Infants with acute lymphoblastic leukaemia (ALL) have a high frequency of central nervous system (CNS) involvement. Flow cytometric analysis of cerebrospinal fluid (CSF) was recently demonstrated to be a sensitive method for detecting CNS involvement in childhood ALL. In the present study, CSF from 14 infants was collected at routine lumbar punctures and analysed by multicolour flow cytometry. At initial diagnosis, leukaemic blasts were detected in CSF by flow cytometry in 11 patients (78·6%) compared to seven patients (50%) by cytospin. Larger studies are needed to determine if CSF flow cytometry has prognostic value in infant ALL.

OriginalsprogEngelsk
TidsskriftBritish Journal of Haematology
Vol/bind195
Udgave nummer1
Sider (fra-til)119-122
Antal sider4
ISSN0007-1048
DOI
StatusUdgivet - okt. 2021

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