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Region Hovedstaden - en del af Københavns Universitetshospital
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Five-Year Change in Choroidal Thickness in Relation to Body Development and Axial Eye Elongation: The CCC2000 Eye Study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Small Hard Macular Drusen and Associations in 11- to 12-Year-Old Children in the Copenhagen Child Cohort 2000 Eye Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Effects of Prenatal Alcohol Exposure on the Visual System of Monkeys Measured at Different Stages of Development

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Problems of feeding, sleeping and excessive crying in infancy: a general population study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Purpose: We describe changes in choroidal thickness from age 11 to 16 years and its association with ocular biometrics and body development.

Method: In this longitudinal, population-based observational study, choroidal thickness was measured subfoveally and 1- and 3-mm temporal thereof using enhanced depth imaging spectral domain optical coherence tomography. Analyses were stratified by sex and adjusted for age and the time of day that the scan was performed.

Results: The study included 687 participants (304 boys). Median (interquartile range [IQR]) age was 11.5 (0.6) years at baseline and 16.6 (0.3) years at follow-up. Mean increase in choroidal thickness was 33, 27, and 11 μm at the three respective locations. The subfoveal choroid thickened less in eyes whose axial length increased more (boys, β = -85 μm/mm; 95% confidence interval [CI], -104 to -66, P < 0.0001; girls, β = -105 μm/mm; 95% CI, -121 to -89, P < 0.0001) and in eyes with a more negative refractive development (boys, 11 μm/diopters [D]; 95% CI, 4.0 to 18, P = 0.0022; girls, 22 μm/D; 95% CI, 16 to 27, P < 0.0001). Subfoveal choroidal thickness increased less in girls who underwent early puberty (Tanner stage 4 vs. 1; -39 μm' 95% CI, -72 to -5.9, P = 0.021) and who had a longer baseline axial length (β = -8.6 μm/mm; 95% CI, -15 to -2.7, P = 0.0043), and more in girls who grew taller (β = 0.9 μm/cm; 95% CI, 0.1 to 1.7, P = 0.026).

Conclusions: The choroid increased in thickness from age 11 to 16 years. The increase was greater in girls with later sexual maturation and smaller in eyes that added more axial length and had a relatively negative refractive development.

OriginalsprogEngelsk
TidsskriftInvestigative ophthalmology & visual science
Vol/bind60
Udgave nummer12
Sider (fra-til)3930-3936
Antal sider7
ISSN0146-0404
DOI
StatusUdgivet - 3 sep. 2019

ID: 58260283