TY - JOUR
T1 - Fitness cost
T2 - a bacteriological explanation for the demise of the first international methicillin-resistant Staphylococcus aureus epidemic
AU - Nielsen, Karen Leth
AU - Pedersen, Thomas
AU - Udekwu, Klas I
AU - Petersen, Andreas
AU - Skov, Robert L
AU - Hansen, Lars
AU - Hughes, Diarmaid
AU - Frimodt-Møller, Niels
N1 - Fitness cost: a bacteriological explanation for the demise of the first international methicillin-resistant Staphylococcus aureus epidemic
Karen L. Nielsen1,2, Thomas M. Pedersen1, Klas I. Udekwu3, Andreas Petersen1, Robert L. Skov1, Lars H. Hansen4, Diarmaid Hughes5 and Niels Frimodt-Møller1,2,*
- Author Affiliations
1Department of Microbiological Surveillance and Research, Statens Serum Institut, Ørestads Boulevard 5, 2300 Copenhagen S, Denmark
2Department of Clinical Microbiology, Hvidovre Hospital, Kettegård Alle 30, 2650 Hvidovre, Denmark
3Department of Neuroscience, Swedish Medical Nanoscience Center, Karolinska Institutet, Retzius väg 8, SE-17177 Stockholm, Sweden
4Department of Microbiology, Institute of Biology, University of Copenhagen, Sølvgade 83H, 1307 Copenhagen, Denmark
5Department of Medical Biochemistry and Microbiology, Uppsala University, Biomedical Center, Box 582, SE-75124 Uppsala, Sweden
↵*Corresponding author. Department of Clinical Microbiology, Hvidovre Hospital, Kettegård Alle 30, 2650 Hvidovre, Denmark. Tel: +45-38-62-16-53; Fax: +45-38-62-33-57; E-mail: [email protected]
PY - 2012/2/29
Y1 - 2012/2/29
N2 - Denmark and several other countries experienced the first epidemic of methicillin-resistant Staphylococcus aureus (MRSA) during the period 1965-75, which was caused by multiresistant isolates of phage complex 83A. In Denmark these MRSA isolates disappeared almost completely, being replaced by other phage types, predominantly only penicillin resistant. We investigated whether isolates of this epidemic were associated with a fitness cost, and we employed a mathematical model to ask whether these fitness costs could have led to the observed reduction in frequency.
AB - Denmark and several other countries experienced the first epidemic of methicillin-resistant Staphylococcus aureus (MRSA) during the period 1965-75, which was caused by multiresistant isolates of phage complex 83A. In Denmark these MRSA isolates disappeared almost completely, being replaced by other phage types, predominantly only penicillin resistant. We investigated whether isolates of this epidemic were associated with a fitness cost, and we employed a mathematical model to ask whether these fitness costs could have led to the observed reduction in frequency.
KW - Bacteriophage Typing
KW - Denmark
KW - Disease Outbreaks
KW - Drug Resistance, Multiple, Bacterial
KW - Energy Metabolism
KW - Humans
KW - Methicillin-Resistant Staphylococcus aureus
KW - Microbial Sensitivity Tests
KW - Models, Theoretical
KW - Staphylococcal Infections
U2 - 10.1093/jac/dks051
DO - 10.1093/jac/dks051
M3 - Journal article
C2 - 22378682
SN - 0305-7453
VL - 67
SP - 1325
EP - 1332
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
IS - 6
ER -