Fitness cost: a bacteriological explanation for the demise of the first international methicillin-resistant Staphylococcus aureus epidemic

Karen Leth Nielsen, Thomas Pedersen, Klas I Udekwu, Andreas Petersen, Robert L Skov, Lars Hansen, Diarmaid Hughes, Niels Frimodt-Møller

43 Citationer (Scopus)

Abstract

Denmark and several other countries experienced the first epidemic of methicillin-resistant Staphylococcus aureus (MRSA) during the period 1965-75, which was caused by multiresistant isolates of phage complex 83A. In Denmark these MRSA isolates disappeared almost completely, being replaced by other phage types, predominantly only penicillin resistant. We investigated whether isolates of this epidemic were associated with a fitness cost, and we employed a mathematical model to ask whether these fitness costs could have led to the observed reduction in frequency.
OriginalsprogEngelsk
TidsskriftJournal of Antimicrobial Chemotherapy
Vol/bind67
Udgave nummer6
Sider (fra-til)1325-32
Antal sider8
ISSN0305-7453
DOI
StatusUdgivet - 29 feb. 2012

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