First-in-man open clinical trial of a combined rdESAT-6 and rCFP-10 tuberculosis specific skin test reagent

Winnie Bergstedt; Pernille N Tingskov; Birgit Thierry-Carstensen; Søren T Hoff; Henrik Aggerbeck; Vibeke Thomsen; Peter Andersen; Åse Bengård Andersen

doi:10.1371/journal.pone.0011277

First-in-man open clinical trial of a combined rdESAT-6 and rCFP-10 tuberculosis specific skin test reagent

Winnie Bergstedt, Pernille N Tingskov, Birgit Thierry-Carstensen, Søren T Hoff, Henrik Aggerbeck, Vibeke Thomsen, Peter Andersen, Åse Bengård Andersen

37 Citationer (Scopus)

Abstract

Tuberculin is still the only available skin test reagent for the diagnosis of mycobacterial infection. The product has a remarkable sensitivity, but poor specificity. Previous studies, including two human phase I clinical trials, have indicated that rdESAT-6 has a potential as an improved skin test reagent. Animal studies have shown that the sensitivity may be increased by inclusion of the genetically related CFP-10 antigen in the preparation without loosing specificity.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	5
Udgave nummer	6
Sider (fra-til)	e11277
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0011277
Status	Udgivet - 1 jan. 2010

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10.1371/journal.pone.0011277

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abstract = "Tuberculin is still the only available skin test reagent for the diagnosis of mycobacterial infection. The product has a remarkable sensitivity, but poor specificity. Previous studies, including two human phase I clinical trials, have indicated that rdESAT-6 has a potential as an improved skin test reagent. Animal studies have shown that the sensitivity may be increased by inclusion of the genetically related CFP-10 antigen in the preparation without loosing specificity.",

author = "Winnie Bergstedt and Tingskov, {Pernille N} and Birgit Thierry-Carstensen and Hoff, {S{\o}ren T} and Henrik Aggerbeck and Vibeke Thomsen and Peter Andersen and Andersen, {{\AA}se Beng{\aa}rd}",

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AU - Bergstedt, Winnie

AU - Tingskov, Pernille N

AU - Thierry-Carstensen, Birgit

AU - Hoff, Søren T

AU - Aggerbeck, Henrik

AU - Thomsen, Vibeke

AU - Andersen, Peter

AU - Andersen, Åse Bengård

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N2 - Tuberculin is still the only available skin test reagent for the diagnosis of mycobacterial infection. The product has a remarkable sensitivity, but poor specificity. Previous studies, including two human phase I clinical trials, have indicated that rdESAT-6 has a potential as an improved skin test reagent. Animal studies have shown that the sensitivity may be increased by inclusion of the genetically related CFP-10 antigen in the preparation without loosing specificity.

AB - Tuberculin is still the only available skin test reagent for the diagnosis of mycobacterial infection. The product has a remarkable sensitivity, but poor specificity. Previous studies, including two human phase I clinical trials, have indicated that rdESAT-6 has a potential as an improved skin test reagent. Animal studies have shown that the sensitivity may be increased by inclusion of the genetically related CFP-10 antigen in the preparation without loosing specificity.

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DO - 10.1371/journal.pone.0011277

M3 - Journal article

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JO - P L o S One

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ER -

First-in-man open clinical trial of a combined rdESAT-6 and rCFP-10 tuberculosis specific skin test reagent

Abstract

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