TY - JOUR
T1 - First-in-man open clinical trial of a combined rdESAT-6 and rCFP-10 tuberculosis specific skin test reagent
AU - Bergstedt, Winnie
AU - Tingskov, Pernille N
AU - Thierry-Carstensen, Birgit
AU - Hoff, Søren T
AU - Aggerbeck, Henrik
AU - Thomsen, Vibeke
AU - Andersen, Peter
AU - Andersen, Åse Bengård
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Tuberculin is still the only available skin test reagent for the diagnosis of mycobacterial infection. The product has a remarkable sensitivity, but poor specificity. Previous studies, including two human phase I clinical trials, have indicated that rdESAT-6 has a potential as an improved skin test reagent. Animal studies have shown that the sensitivity may be increased by inclusion of the genetically related CFP-10 antigen in the preparation without loosing specificity.
AB - Tuberculin is still the only available skin test reagent for the diagnosis of mycobacterial infection. The product has a remarkable sensitivity, but poor specificity. Previous studies, including two human phase I clinical trials, have indicated that rdESAT-6 has a potential as an improved skin test reagent. Animal studies have shown that the sensitivity may be increased by inclusion of the genetically related CFP-10 antigen in the preparation without loosing specificity.
U2 - 10.1371/journal.pone.0011277
DO - 10.1371/journal.pone.0011277
M3 - Journal article
C2 - 20593018
SN - 1932-6203
VL - 5
SP - e11277
JO - P L o S One
JF - P L o S One
IS - 6
ER -