Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Combined burden and functional impact tests for cancer driver discovery using DriverPower

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Genomic footprints of activated telomere maintenance mechanisms in cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Pathway and network analysis of more than 2500 whole cancer genomes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Prenatal dietary supplements influence the infant airway microbiota in a randomized factorial clinical trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Transcriptome-wide association study reveals candidate causal genes for lung cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Reply to: Clinical impact of high platelet count and high hematocrit, by Marc Sorigue

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. A network analysis to identify mediators of germline-driven differences in breast cancer prognosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Incidental lymphopenia and mortality: a prospective cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Aida Ferreiro-Iglesias
  • Corina Lesseur
  • James McKay
  • Rayjean J Hung
  • Younghun Han
  • Xuchen Zong
  • David Christiani
  • Mattias Johansson
  • Xiangjun Xiao
  • Yafang Li
  • David C Qian
  • Xuemei Ji
  • Geoffrey Liu
  • Neil Caporaso
  • Ghislaine Scelo
  • David Zaridze
  • Anush Mukeriya
  • Milica Kontic
  • Simona Ognjanovic
  • Jolanta Lissowska
  • Małgorzata Szołkowska
  • Beata Swiatkowska
  • Vladimir Janout
  • Ivana Holcatova
  • Ciprian Bolca
  • Milan Savic
  • Miodrag Ognjanovic
  • Stig Egil Bojesen
  • Xifeng Wu
  • Demetrios Albanes
  • Melinda C Aldrich
  • Adonina Tardon
  • Ana Fernandez-Somoano
  • Guillermo Fernandez-Tardon
  • Loic Le Marchand
  • Gadi Rennert
  • Chu Chen
  • Jennifer Doherty
  • Gary Goodman
  • Heike Bickeböller
  • H-Erich Wichmann
  • Angela Risch
  • Albert Rosenberger
  • Hongbing Shen
  • Juncheng Dai
  • John K Field
  • Michael Davies
  • Penella Woll
  • M Dawn Teare
  • Lambertus A Kiemeney
  • Erik H F M van der Heijden
  • Jian-Min Yuan
  • Yun-Chul Hong
  • Aage Haugen
  • Shanbeh Zienolddiny
  • Stephen Lam
  • Ming-Sound Tsao
  • Mikael Johansson
  • Kjell Grankvist
  • Matthew B Schabath
  • Angeline Andrew
  • Eric Duell
  • Olle Melander
  • Hans Brunnström
  • Philip Lazarus
  • Susanne Arnold
  • Stacey Slone
  • Jinyoung Byun
  • Ahsan Kamal
  • Dakai Zhu
  • Maria Teresa Landi
  • Christopher I Amos
  • Paul Brennan
Vis graf over relationer

Lung cancer has several genetic associations identified within the major histocompatibility complex (MHC); although the basis for these associations remains elusive. Here, we analyze MHC genetic variation among 26,044 lung cancer patients and 20,836 controls densely genotyped across the MHC, using the Illumina Illumina OncoArray or Illumina 660W SNP microarray. We impute sequence variation in classical HLA genes, fine-map MHC associations for lung cancer risk with major histologies and compare results between ethnicities. Independent and novel associations within HLA genes are identified in Europeans including amino acids in the HLA-B*0801 peptide binding groove and an independent HLA-DQB1*06 loci group. In Asians, associations are driven by two independent HLA allele sets that both increase risk in HLA-DQB1*0401 and HLA-DRB1*0701; the latter better represented by the amino acid Ala-104. These results implicate several HLA-tumor peptide interactions as the major MHC factor modulating lung cancer susceptibility.

OriginalsprogEngelsk
TidsskriftNature Communications
Vol/bind9
Udgave nummer1
Sider (fra-til)3927
ISSN2041-1723
DOI
StatusUdgivet - 25 sep. 2018

ID: 56639882