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Region Hovedstaden - en del af Københavns Universitetshospital
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Finding of IDH1 R132H mutation in histologically non-neoplastic glial tissue changes surgical strategies, a case report

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DOI

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Vis graf over relationer

INTRODUCTION: In 2016, the WHO classification of diffuse astrocytoma began to include isocitrate dehydrogenase (IDH) mutation in addition to histology.

RESULTS: We here demonstrate a case where a 14-year-old boy presented with a parietal tumor with no histological evidence of neoplasia but with an IDH1 mutation. Due to the IDH1 R132H mutation, the patient was diagnosed with diffuse astrocytoma WHO grade II and underwent successful gross total resection of this near-eloquently located tumor.

CONCLUSION: This case exemplifies how inclusion of immunohistochemistry in tumor classification alters surgical strategy and might improve accuracy and time to diagnosis.

OriginalsprogEngelsk
TidsskriftChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
Vol/bind33
Udgave nummer7
Sider (fra-til)1217-1220
ISSN0256-7040
DOI
StatusUdgivet - jul. 2017

ID: 49947654