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Region Hovedstaden - en del af Københavns Universitetshospital
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Finding of IDH1 R132H mutation in histologically non-neoplastic glial tissue changes surgical strategies, a case report

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  1. Introduction to the cerebellar mutism syndrome

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  2. The supplementary motor area syndrome and the cerebellar mutism syndrome: a pathoanatomical relationship?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Telemetric intracranial pressure monitoring in children

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Consensus paper on post-operative pediatric cerebellar mutism syndrome: the Iceland Delphi results

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  1. Isolated Ocular Sarcoidosis Mimicking Ring Melanoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Systemic Immune Modulation in Gliomas: Prognostic Value of Plasma IL-6, YKL-40, and Genetic Variation in YKL-40

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. WHO grade I meningiomas: classification-tree for prognostic factors of survival

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Organisering af Perifer Nervekirurgi i Danmark

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Vis graf over relationer

INTRODUCTION: In 2016, the WHO classification of diffuse astrocytoma began to include isocitrate dehydrogenase (IDH) mutation in addition to histology.

RESULTS: We here demonstrate a case where a 14-year-old boy presented with a parietal tumor with no histological evidence of neoplasia but with an IDH1 mutation. Due to the IDH1 R132H mutation, the patient was diagnosed with diffuse astrocytoma WHO grade II and underwent successful gross total resection of this near-eloquently located tumor.

CONCLUSION: This case exemplifies how inclusion of immunohistochemistry in tumor classification alters surgical strategy and might improve accuracy and time to diagnosis.

OriginalsprogEngelsk
TidsskriftChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
Vol/bind33
Udgave nummer7
Sider (fra-til)1217-1220
ISSN0256-7040
DOI
StatusUdgivet - jul. 2017

ID: 49947654