Fetal Gender and Several Cytokines Are Associated with the Number of Fetal Cells in Maternal Blood - An Observational Study

Jacob Mørup Schlütter; Ida Sejersdahl Kirkegaard; Olav Bjørn Petersen; Nanna Larsen; Britta Christensen; David M Hougaard; Steen Kølvraa; Niels Uldbjerg

doi:10.1371/journal.pone.0106934

Fetal Gender and Several Cytokines Are Associated with the Number of Fetal Cells in Maternal Blood - An Observational Study

Jacob Mørup Schlütter, Ida Sejersdahl Kirkegaard, Olav Bjørn Petersen, Nanna Larsen, Britta Christensen, David M Hougaard, Steen Kølvraa, Niels Uldbjerg

17 Citationer (Scopus)

Abstract

OBJECTIVE: To identify factors influencing the number of fetal cells in maternal blood.

METHODS: A total of 57 pregnant women at a gestational age of weeks 11-14 were included. The number of fetal cells in maternal blood was assessed in 30 ml of blood using specific markers for both enrichment and subsequent identification.

RESULTS: Participants carrying male fetuses had a higher median number of fetal cells in maternal blood than those carrying female fetuses (5 vs. 3, p = 0.04). Certain cytokines (RANTES, IL-2 and IL-5) were significantly associated with the number of fetal cells in maternal blood.

CONCLUSION: The number of fetal cells in maternal blood is associated with certain cytokines and fetal gender.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	9
Udgave nummer	9
Sider (fra-til)	e106934
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0106934
Status	Udgivet - 4 sep. 2014
Udgivet eksternt	Ja

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10.1371/journal.pone.0106934

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title = "Fetal Gender and Several Cytokines Are Associated with the Number of Fetal Cells in Maternal Blood - An Observational Study",

abstract = "OBJECTIVE: To identify factors influencing the number of fetal cells in maternal blood.METHODS: A total of 57 pregnant women at a gestational age of weeks 11-14 were included. The number of fetal cells in maternal blood was assessed in 30 ml of blood using specific markers for both enrichment and subsequent identification.RESULTS: Participants carrying male fetuses had a higher median number of fetal cells in maternal blood than those carrying female fetuses (5 vs. 3, p = 0.04). Certain cytokines (RANTES, IL-2 and IL-5) were significantly associated with the number of fetal cells in maternal blood.CONCLUSION: The number of fetal cells in maternal blood is associated with certain cytokines and fetal gender.",

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T1 - Fetal Gender and Several Cytokines Are Associated with the Number of Fetal Cells in Maternal Blood - An Observational Study

AU - Schlütter, Jacob Mørup

AU - Kirkegaard, Ida Sejersdahl

AU - Petersen, Olav Bjørn

AU - Larsen, Nanna

AU - Christensen, Britta

AU - Hougaard, David M

AU - Kølvraa, Steen

AU - Uldbjerg, Niels

PY - 2014/9/4

Y1 - 2014/9/4

N2 - OBJECTIVE: To identify factors influencing the number of fetal cells in maternal blood.METHODS: A total of 57 pregnant women at a gestational age of weeks 11-14 were included. The number of fetal cells in maternal blood was assessed in 30 ml of blood using specific markers for both enrichment and subsequent identification.RESULTS: Participants carrying male fetuses had a higher median number of fetal cells in maternal blood than those carrying female fetuses (5 vs. 3, p = 0.04). Certain cytokines (RANTES, IL-2 and IL-5) were significantly associated with the number of fetal cells in maternal blood.CONCLUSION: The number of fetal cells in maternal blood is associated with certain cytokines and fetal gender.

AB - OBJECTIVE: To identify factors influencing the number of fetal cells in maternal blood.METHODS: A total of 57 pregnant women at a gestational age of weeks 11-14 were included. The number of fetal cells in maternal blood was assessed in 30 ml of blood using specific markers for both enrichment and subsequent identification.RESULTS: Participants carrying male fetuses had a higher median number of fetal cells in maternal blood than those carrying female fetuses (5 vs. 3, p = 0.04). Certain cytokines (RANTES, IL-2 and IL-5) were significantly associated with the number of fetal cells in maternal blood.CONCLUSION: The number of fetal cells in maternal blood is associated with certain cytokines and fetal gender.

U2 - 10.1371/journal.pone.0106934

DO - 10.1371/journal.pone.0106934

M3 - Journal article

C2 - 25188498

SN - 1932-6203

VL - 9

SP - e106934

JO - P L o S One

JF - P L o S One

IS - 9

ER -

Fetal Gender and Several Cytokines Are Associated with the Number of Fetal Cells in Maternal Blood - An Observational Study

Abstract

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