Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Fertility preservation in boys facing gonadotoxic cancer therapy

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

  1. Late adverse effects and quality of life in survivors of testicular germ cell tumour

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. COVID and CopMich: comparing and contrasting COVID-19 experiences in the USA and Scandinavia

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  3. Application of miRNAs in the diagnosis and monitoring of testicular germ cell tumours

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Oxytocin antagonists: the next frontier in PE treatment

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. From separation to collaboration: the future of urology

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

Vis graf over relationer

Patient survival following childhood cancer has increased with contemporary radiation and chemotherapy techniques. However, gonadotoxicity associated with treatments means that infertility is a common consequence in survivors. Novel fertility preservation options are emerging, but knowledge about these options amongst urologists and other medical professionals is lacking. Pre-pubertal boys generally do not produce haploid germ cells. Thus, strategies for fertility preservation require cryopreservation of tissue containing spermatogonial stem cells (SSCs). Few centres worldwide routinely offer this option and fertility restoration (including testicular tissue engraftment, autotransplantation of SSCs and in vitro maturation of SSCs to spermatozoa) post-thaw is experimental. In pubertal boys, the main option for fertility preservation is masturbation and cryopreservation of the ejaculate. Assisted ejaculation using penile vibratory stimulation or electroejaculation and surgical sperm retrieval can be used in a sequential manner after failed masturbation. Physicians should inform boys and parents about the gonadotoxic effects of cancer treatment and offer fertility preservation. Preclinical experience has identified challenges in pre-pubertal fertility preservation, but available options are expected to be successful when today's pre-pubertal boys with cancer become adults. By contrast, fertility preservation in pubertal boys is clinically proven and should be offered to all patients undergoing cancer treatment.

OriginalsprogEngelsk
TidsskriftNature reviews. Urology
Vol/bind19
Udgave nummer2
Sider (fra-til)71-83
Antal sider13
ISSN1759-4812
DOI
StatusUdgivet - feb. 2022

Bibliografisk note

© 2021. Springer Nature Limited.

ID: 68557957