Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Fecal Microbiota Transplantation in the Treatment of Chronic Pouchitis: A Systematic Review

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{d78b9930fdc74b11b79eac5448d568d5,
title = "Fecal Microbiota Transplantation in the Treatment of Chronic Pouchitis: A Systematic Review",
abstract = "The objective was to evaluate available literature on treatment of chronic pouchitis with fecal microbiota transplantation (FMT) focusing on clinical outcomes, safety, and different approaches to FMT preparation and delivery. A systematic review of electronic databases was conducted using Medline, EMBASE, and the Cochrane Central Register of Controlled Trials Library from inception through April 2020. Human studies of all study types reporting results of FMT to treat chronic pouchitis were included. Nine studies, reporting FMT treatment of 69 patients with chronic pouchitis were found eligible for the review. Most studies were case series and cohort studies rated as having fair to poor quality due to high risk of bias and small sample size. Only one randomized controlled trial was included, finding no beneficial effect of FMT. In total clinical response after FMT was reported in 14 (31.8%) out of 44 evaluated patients at various timepoints after FMT, and clinical remission in ten (22.7%) patients. Only minor self-limiting adverse events were reported. FMT varied greatly regarding preparation, length of treatment, and route of delivery. The effects of FMT on symptoms of chronic pouchitis are not established, though some studies show promising results. Future controlled well-designed studies are warranted.",
keywords = "Fecal microbiota transplantation, IPAA, Microbiota, Pouchitis",
author = "Frederik Cold and Kousgaard, {Sabrina Just} and Halkjaer, {Sofie Ingdam} and Petersen, {Andreas Munk} and Nielsen, {Hans Linde} and Ole Thorlacius-Ussing and Hansen, {Lars Hestbjerg}",
year = "2020",
month = sep,
day = "1",
doi = "10.3390/microorganisms8091433",
language = "English",
volume = "8",
pages = "1--18",
journal = "Microorganisms",
issn = "2076-2607",
publisher = "M D P I AG",
number = "9",

}

RIS

TY - JOUR

T1 - Fecal Microbiota Transplantation in the Treatment of Chronic Pouchitis

T2 - A Systematic Review

AU - Cold, Frederik

AU - Kousgaard, Sabrina Just

AU - Halkjaer, Sofie Ingdam

AU - Petersen, Andreas Munk

AU - Nielsen, Hans Linde

AU - Thorlacius-Ussing, Ole

AU - Hansen, Lars Hestbjerg

PY - 2020/9/1

Y1 - 2020/9/1

N2 - The objective was to evaluate available literature on treatment of chronic pouchitis with fecal microbiota transplantation (FMT) focusing on clinical outcomes, safety, and different approaches to FMT preparation and delivery. A systematic review of electronic databases was conducted using Medline, EMBASE, and the Cochrane Central Register of Controlled Trials Library from inception through April 2020. Human studies of all study types reporting results of FMT to treat chronic pouchitis were included. Nine studies, reporting FMT treatment of 69 patients with chronic pouchitis were found eligible for the review. Most studies were case series and cohort studies rated as having fair to poor quality due to high risk of bias and small sample size. Only one randomized controlled trial was included, finding no beneficial effect of FMT. In total clinical response after FMT was reported in 14 (31.8%) out of 44 evaluated patients at various timepoints after FMT, and clinical remission in ten (22.7%) patients. Only minor self-limiting adverse events were reported. FMT varied greatly regarding preparation, length of treatment, and route of delivery. The effects of FMT on symptoms of chronic pouchitis are not established, though some studies show promising results. Future controlled well-designed studies are warranted.

AB - The objective was to evaluate available literature on treatment of chronic pouchitis with fecal microbiota transplantation (FMT) focusing on clinical outcomes, safety, and different approaches to FMT preparation and delivery. A systematic review of electronic databases was conducted using Medline, EMBASE, and the Cochrane Central Register of Controlled Trials Library from inception through April 2020. Human studies of all study types reporting results of FMT to treat chronic pouchitis were included. Nine studies, reporting FMT treatment of 69 patients with chronic pouchitis were found eligible for the review. Most studies were case series and cohort studies rated as having fair to poor quality due to high risk of bias and small sample size. Only one randomized controlled trial was included, finding no beneficial effect of FMT. In total clinical response after FMT was reported in 14 (31.8%) out of 44 evaluated patients at various timepoints after FMT, and clinical remission in ten (22.7%) patients. Only minor self-limiting adverse events were reported. FMT varied greatly regarding preparation, length of treatment, and route of delivery. The effects of FMT on symptoms of chronic pouchitis are not established, though some studies show promising results. Future controlled well-designed studies are warranted.

KW - Fecal microbiota transplantation

KW - IPAA

KW - Microbiota

KW - Pouchitis

UR - http://www.scopus.com/inward/record.url?scp=85091113436&partnerID=8YFLogxK

U2 - 10.3390/microorganisms8091433

DO - 10.3390/microorganisms8091433

M3 - Review

C2 - 32962069

VL - 8

SP - 1

EP - 18

JO - Microorganisms

JF - Microorganisms

SN - 2076-2607

IS - 9

M1 - 1433

ER -

ID: 60898093