TY - JOUR
T1 - Feasibility of a novel liquid fiducial marker for use in image guided radiotherapy of oesophageal cancer
AU - de Blanck, Steen Riisgaard
AU - Scherman-Rydhög, Jonas
AU - Siemsen, Mette
AU - Christensen, Merete
AU - Baeksgaard, Lene
AU - Irming Jølck, Rasmus
AU - Specht, Lena
AU - Andresen, Thomas Lars
AU - Persson, Gitte Fredberg
PY - 2018
Y1 - 2018
N2 - OBJECTIVE:: To evaluate the feasibility of a new liquid fiducial marker for use in image-guided radiotherapy for oesophageal cancer.METHODS:: Liquid fiducial markers were implanted in patients with metastatic or inoperable locally advanced oesophageal or gastro-oesophageal junction cancer receiving radiotherapy. Markers were implanted using a conventional gastroscope equipped with a 22 G Wang needle. Marker visibility was evaluated on fluoroscopy, CT, MRI and cone beam CT scans.RESULTS:: Liquid markers (n = 16) were injected in four patients. No Grade 2 or worse adverse events were observed in relation to the implantation procedure, during treatment or in the follow-up period. 12/16 (75%) markers were available at the planning CT-scan and throughout the treatment- and follow-up period. The implanted markers were adequately visible in CT and cone beam CT but were difficult to distinguish in fluoroscopy and MRI without information from the corresponding CT image.CONCLUSION:: Liquid fiducial marker placement in the oesophagus proved safe and clinically feasible.ADVANCES IN KNOWLEDGE:: This paper presents the first clinical use of a new liquid fiducial marker in patients with oesophageal cancer and demonstrates that marker implantation using standard gastroscopic equipment and subsequent use in three-dimensional image-guided radiation therapy is safe and clinically feasible.
AB - OBJECTIVE:: To evaluate the feasibility of a new liquid fiducial marker for use in image-guided radiotherapy for oesophageal cancer.METHODS:: Liquid fiducial markers were implanted in patients with metastatic or inoperable locally advanced oesophageal or gastro-oesophageal junction cancer receiving radiotherapy. Markers were implanted using a conventional gastroscope equipped with a 22 G Wang needle. Marker visibility was evaluated on fluoroscopy, CT, MRI and cone beam CT scans.RESULTS:: Liquid markers (n = 16) were injected in four patients. No Grade 2 or worse adverse events were observed in relation to the implantation procedure, during treatment or in the follow-up period. 12/16 (75%) markers were available at the planning CT-scan and throughout the treatment- and follow-up period. The implanted markers were adequately visible in CT and cone beam CT but were difficult to distinguish in fluoroscopy and MRI without information from the corresponding CT image.CONCLUSION:: Liquid fiducial marker placement in the oesophagus proved safe and clinically feasible.ADVANCES IN KNOWLEDGE:: This paper presents the first clinical use of a new liquid fiducial marker in patients with oesophageal cancer and demonstrates that marker implantation using standard gastroscopic equipment and subsequent use in three-dimensional image-guided radiation therapy is safe and clinically feasible.
KW - Aged
KW - Cone-Beam Computed Tomography
KW - Esophageal Neoplasms/diagnostic imaging
KW - Feasibility Studies
KW - Fiducial Markers
KW - Humans
KW - Radiotherapy, Image-Guided/methods
KW - Tomography, X-Ray Computed
U2 - 10.1259/bjr.20180236
DO - 10.1259/bjr.20180236
M3 - Journal article
C2 - 29975152
SN - 0007-1285
VL - 91
SP - 20180236
JO - The British journal of radiology
JF - The British journal of radiology
IS - 1092
ER -