Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Feasibility and usability of real-time intraoperative quantitative fluorescent-guided perfusion assessment during resection of gastroesophageal junction cancer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Surgical management of acute cholecystitis in a nationwide Danish cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Laser speckle contrast imaging and quantitative fluorescence angiography for perfusion assessment

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Using computerized assessment in simulated colonoscopy: a validation study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The Incidence of Free Peritoneal Tumor Cells before and after Neoadjuvant Chemotherapy in Gastroesophageal Junction Cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Optimizing quantitative fluorescence angiography for visceral perfusion assessment

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

Purpose: Anastomotic leakage after resection of gastroesophageal junction cancer is a dangerous complication, and leakage rates have remained stable for decades. Perfusion is crucial for anastomotic healing, but traditional perfusion assessment is limited in a minimally invasive environment. New methods as indocyanine green fluorescence angiography (ICG-FA) have proven promising, but quantitative analysis has been challenging. This study aimed to demonstrate the feasibility and usability of real-time intraoperative quantitative fluorescence angiography (q-ICG) with a touchscreen tablet. Methods: A software for q-ICG was previously developed and validated. Ten patients underwent perfusion assessment in white light (WL), with ICG-FA, and with q-ICG during Ivor-Lewis esophageal resection. The usability of the tablet-based software was tested with the System Usability Scale (SUS®). Furthermore, we investigated the differences in perfusion assessment as the distance from the conduit margin to a surgeon selected point of sufficient perfusion for anastomosis using the different modalities. Results: Q-ICG was successful in all patients, with an excellent median SUS® of 82.5 (77.5–93.8). Significant differences in distances from the conduit margin to points of sufficient perfusion selected by the surgeons were found: ICG: WL = 14.1 mm (p = 0.048), q-ICG: WL = 32.08 mm (p < 0.001), and q-ICG: ICG = 17.95 mm (p = 0.002). Furthermore, significant differences of perfusion were found between the points, when q-ICG was performed retrospectively in the surgeon selected areas (p = 0.008–0.013). Conclusion: Real-time intraoperative touchscreen-based q-ICG was feasible with excellent usability, and differences in sufficient perfusion points selected by the surgeons between modalities were found. Further studies should focus on clinical relevance and determine cutoff values associated with anastomotic leakage.

OriginalsprogEngelsk
TidsskriftLangenbeck's Archives of Surgery
ISSN1435-2443
DOI
StatusUdgivet - 1 jan. 2020

ID: 59910812