Fc gamma receptor 3B (FCGR3B-c.233C>A-rs5030738) polymorphism modifies the protective effect of malaria specific antibodies in Ghanaian children

Bright Adu; Micha Phill Grønholm Jepsen; Thomas A Gerds; Eric Kyei-Baafour; Michael Christiansen; Daniel Dodoo; Michael Theisen

doi:10.1093/infdis/jit422

Fc gamma receptor 3B (FCGR3B-c.233C>A-rs5030738) polymorphism modifies the protective effect of malaria specific antibodies in Ghanaian children

Bright Adu, Micha Phill Grønholm Jepsen, Thomas A Gerds, Eric Kyei-Baafour, Michael Christiansen, Daniel Dodoo, Michael Theisen

25 Citationer (Scopus)

Abstract

Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcγRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcγRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C>A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies.

Originalsprog	Engelsk
Tidsskrift	The Journal of infectious diseases
Vol/bind	209
Udgave nummer	2
Sider (fra-til)	285-9
Antal sider	5
ISSN	0022-1899
DOI	https://doi.org/10.1093/infdis/jit422
Status	Udgivet - 15 jan. 2014

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10.1093/infdis/jit422

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Fc gamma receptor 3B (FCGR3B-c.233C>A-rs5030738) polymorphism modifies the protective effect of malaria specific antibodies in Ghanaian children. / Adu, Bright; Jepsen, Micha Phill Grønholm; Gerds, Thomas A et al.
I: The Journal of infectious diseases, Bind 209, Nr. 2, 15.01.2014, s. 285-9.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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title = "Fc gamma receptor 3B (FCGR3B-c.233C>A-rs5030738) polymorphism modifies the protective effect of malaria specific antibodies in Ghanaian children",

abstract = "Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcγRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcγRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C>A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies.",

keywords = "Antibodies, Protozoan, Child, Child, Preschool, Cohort Studies, Female, GPI-Linked Proteins, Genetic Predisposition to Disease, Ghana, Humans, Infant, Malaria, Male, Polymorphism, Single Nucleotide, Receptors, IgG",

author = "Bright Adu and Jepsen, {Micha Phill Gr{\o}nholm} and Gerds, {Thomas A} and Eric Kyei-Baafour and Michael Christiansen and Daniel Dodoo and Michael Theisen",

year = "2014",

month = jan,

day = "15",

doi = "10.1093/infdis/jit422",

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volume = "209",

pages = "285--9",

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TY - JOUR

T1 - Fc gamma receptor 3B (FCGR3B-c.233C>A-rs5030738) polymorphism modifies the protective effect of malaria specific antibodies in Ghanaian children

AU - Adu, Bright

AU - Jepsen, Micha Phill Grønholm

AU - Gerds, Thomas A

AU - Kyei-Baafour, Eric

AU - Christiansen, Michael

AU - Dodoo, Daniel

AU - Theisen, Michael

PY - 2014/1/15

Y1 - 2014/1/15

N2 - Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcγRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcγRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C>A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies.

AB - Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcγRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcγRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein antibodies and FCGR3B-c.233C>A genotypes on risk of malaria in a cohort of Ghanaian children. The absolute risk of malaria decreased more rapidly with increasing antibody levels for 233AA/AC individuals compared with 233CC children. This genotype related effect modification may significantly influence malaria sero-epidemiological and vaccine trial studies.

KW - Antibodies, Protozoan

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Female

KW - GPI-Linked Proteins

KW - Genetic Predisposition to Disease

KW - Ghana

KW - Humans

KW - Infant

KW - Malaria

KW - Male

KW - Polymorphism, Single Nucleotide

KW - Receptors, IgG

U2 - 10.1093/infdis/jit422

DO - 10.1093/infdis/jit422

M3 - Journal article

C2 - 23935200

SN - 0022-1899

VL - 209

SP - 285

EP - 289

JO - The Journal of infectious diseases

JF - The Journal of infectious diseases

IS - 2

ER -

Fc gamma receptor 3B (FCGR3B-c.233C>A-rs5030738) polymorphism modifies the protective effect of malaria specific antibodies in Ghanaian children

Abstract

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