Fatal SARS-CoV-2-Associated Panton-Valentine Leukocidin-producing Staphylococcal Bacteremia: A Nationwide Multicenter Cohort Study

Ulrikka Nygaard; Andreas Petersen; Anders Rhod Larsen; Maren Johanne Heilskov Rytter; Ulla Hartling; Nikolai Kirkby; Rikke Nymark Hansen; Allan Bybeck Nielsen; Kaare Lundstrøm; Mette Holm; Nadja Hawwa Vissing

doi:10.1097/INF.0000000000003476

Fatal SARS-CoV-2-Associated Panton-Valentine Leukocidin-producing Staphylococcal Bacteremia: A Nationwide Multicenter Cohort Study

Ulrikka Nygaard^*, Andreas Petersen, Anders Rhod Larsen, Maren Johanne Heilskov Rytter, Ulla Hartling, Nikolai Kirkby, Rikke Nymark Hansen, Allan Bybeck Nielsen, Kaare Lundstrøm, Mette Holm, Nadja Hawwa Vissing

^*Corresponding author af dette arbejde

Abstract

We reviewed all cases of Panton-Valentine leukocidin-producing Staphylococcus aureus (PVL-SA) bacteremia in Danish children between 2016 and 2021. We found 2 fatal cases with preceding viral prodrome due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Given the usual benign course of SARS-CoV-2 infection in children, awareness of possible superinfection with PVL-SA in a child with rapid deterioration is crucial to ensure adequate treatment, including antimicrobial drugs with antitoxin effect.

Originalsprog	Engelsk
Tidsskrift	The Pediatric infectious disease journal
Vol/bind	41
Udgave nummer	4
Sider (fra-til)	e142-e145
ISSN	0891-3668
DOI	https://doi.org/10.1097/INF.0000000000003476
Status	Udgivet - 1 apr. 2022

Adgang til dokumentet

10.1097/INF.0000000000003476

Citationsformater

Nygaard, U., Petersen, A., Larsen, A. R., Rytter, M. J. H., Hartling, U., Kirkby, N., Hansen, R. N., Nielsen, A. B., Lundstrøm, K., Holm, M., & Vissing, N. H. (2022). Fatal SARS-CoV-2-Associated Panton-Valentine Leukocidin-producing Staphylococcal Bacteremia: A Nationwide Multicenter Cohort Study. The Pediatric infectious disease journal, 41(4), e142-e145. https://doi.org/10.1097/INF.0000000000003476

Fatal SARS-CoV-2-Associated Panton-Valentine Leukocidin-producing Staphylococcal Bacteremia: A Nationwide Multicenter Cohort Study. / Nygaard, Ulrikka; Petersen, Andreas; Larsen, Anders Rhod et al.
I: The Pediatric infectious disease journal, Bind 41, Nr. 4, 01.04.2022, s. e142-e145.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Nygaard, U, Petersen, A, Larsen, AR, Rytter, MJH, Hartling, U, Kirkby, N, Hansen, RN, Nielsen, AB, Lundstrøm, K, Holm, M & Vissing, NH 2022, 'Fatal SARS-CoV-2-Associated Panton-Valentine Leukocidin-producing Staphylococcal Bacteremia: A Nationwide Multicenter Cohort Study', The Pediatric infectious disease journal, bind 41, nr. 4, s. e142-e145. https://doi.org/10.1097/INF.0000000000003476

@article{b553c266bc714da486595dafee2de3c6,

title = "Fatal SARS-CoV-2-Associated Panton-Valentine Leukocidin-producing Staphylococcal Bacteremia: A Nationwide Multicenter Cohort Study",

abstract = "We reviewed all cases of Panton-Valentine leukocidin-producing Staphylococcus aureus (PVL-SA) bacteremia in Danish children between 2016 and 2021. We found 2 fatal cases with preceding viral prodrome due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Given the usual benign course of SARS-CoV-2 infection in children, awareness of possible superinfection with PVL-SA in a child with rapid deterioration is crucial to ensure adequate treatment, including antimicrobial drugs with antitoxin effect.",

keywords = "Adolescent, Bacteremia, Bacterial Toxins/biosynthesis, COVID-19/complications, Child, Child, Preschool, Coinfection, Comorbidity, Denmark/epidemiology, Exotoxins/biosynthesis, Female, Humans, Infant, Leukocidins/biosynthesis, Male, Methicillin-Resistant Staphylococcus aureus/genetics, Public Health Surveillance, SARS-CoV-2, Severity of Illness Index, Staphylococcal Infections/diagnosis, Staphylococcus aureus/drug effects",

author = "Ulrikka Nygaard and Andreas Petersen and Larsen, {Anders Rhod} and Rytter, {Maren Johanne Heilskov} and Ulla Hartling and Nikolai Kirkby and Hansen, {Rikke Nymark} and Nielsen, {Allan Bybeck} and Kaare Lundstr{\o}m and Mette Holm and Vissing, {Nadja Hawwa}",

year = "2022",

month = apr,

day = "1",

doi = "10.1097/INF.0000000000003476",

language = "English",

volume = "41",

pages = "e142--e145",

journal = "The Pediatric infectious disease journal",

issn = "0891-3668",

publisher = "Lippincott Williams & Wilkins",

number = "4",

}

TY - JOUR

T1 - Fatal SARS-CoV-2-Associated Panton-Valentine Leukocidin-producing Staphylococcal Bacteremia

T2 - A Nationwide Multicenter Cohort Study

AU - Nygaard, Ulrikka

AU - Petersen, Andreas

AU - Larsen, Anders Rhod

AU - Rytter, Maren Johanne Heilskov

AU - Hartling, Ulla

AU - Kirkby, Nikolai

AU - Hansen, Rikke Nymark

AU - Nielsen, Allan Bybeck

AU - Lundstrøm, Kaare

AU - Holm, Mette

AU - Vissing, Nadja Hawwa

PY - 2022/4/1

Y1 - 2022/4/1

N2 - We reviewed all cases of Panton-Valentine leukocidin-producing Staphylococcus aureus (PVL-SA) bacteremia in Danish children between 2016 and 2021. We found 2 fatal cases with preceding viral prodrome due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Given the usual benign course of SARS-CoV-2 infection in children, awareness of possible superinfection with PVL-SA in a child with rapid deterioration is crucial to ensure adequate treatment, including antimicrobial drugs with antitoxin effect.

AB - We reviewed all cases of Panton-Valentine leukocidin-producing Staphylococcus aureus (PVL-SA) bacteremia in Danish children between 2016 and 2021. We found 2 fatal cases with preceding viral prodrome due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Given the usual benign course of SARS-CoV-2 infection in children, awareness of possible superinfection with PVL-SA in a child with rapid deterioration is crucial to ensure adequate treatment, including antimicrobial drugs with antitoxin effect.

KW - Adolescent

KW - Bacteremia

KW - Bacterial Toxins/biosynthesis

KW - COVID-19/complications

KW - Child

KW - Child, Preschool

KW - Coinfection

KW - Comorbidity

KW - Denmark/epidemiology

KW - Exotoxins/biosynthesis

KW - Female

KW - Humans

KW - Infant

KW - Leukocidins/biosynthesis

KW - Male

KW - Methicillin-Resistant Staphylococcus aureus/genetics

KW - Public Health Surveillance

KW - SARS-CoV-2

KW - Severity of Illness Index

KW - Staphylococcal Infections/diagnosis

KW - Staphylococcus aureus/drug effects

U2 - 10.1097/INF.0000000000003476

DO - 10.1097/INF.0000000000003476

M3 - Journal article

C2 - 35093994

SN - 0891-3668

VL - 41

SP - e142-e145

JO - The Pediatric infectious disease journal

JF - The Pediatric infectious disease journal

IS - 4

ER -

Fatal SARS-CoV-2-Associated Panton-Valentine Leukocidin-producing Staphylococcal Bacteremia: A Nationwide Multicenter Cohort Study

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater