Fatal cerebral blødning på grund af mulig interaktionmellem paracetamol og warfarin

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Abstract

This is a case report of an 83-year-old man in warfarin treatment with stable international normalised ratio (INR) after aortic valve replacement and atrial fibrillation. Due to back pain he took paracetamol (acetaminophen) 4 g/day, morphine 30 mg/day and diclofenac as rescue medication for two weeks. After 14 days of treatment he was admitted to a hospital with acute neurological deficits, and a blood sample showed INR levels above 10. A CT-scan of the brain showed an intracerebral haemorrhage. The patient died eight days after admission. Mechanisms of the possible interaction between paracetamol and warfarin are discussed.

Bidragets oversatte titelFatal intracerebral haemorrhage possibly caused by interaction between paracetamol and warfarin
OriginalsprogDansk
TidsskriftUgeskrift for Laeger
Vol/bind177
Udgave nummer23
Sider (fra-til)V12140685
ISSN0041-5782
StatusUdgivet - 1 jun. 2015

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