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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Fat Replacement of Paraspinal Muscles with Aging in Healthy Adults

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Vis graf over relationer

PURPOSE: The aim of this study was to investigate the age-related changes in fatty replacement and cross sectional area (CSA) of cervical, thoracic and lumbar paraspinal muscles vs. leg muscles in healthy adults, and to test for association between muscle fat fraction and lifestyle factors.

METHODS: Fifty-three healthy adults (24-76 years) were included. Dixon MRI technique was used to determine CSA and quantify fat fraction of paraspinal and leg muscles. Muscle CSA and fat fractions were tested for association with age and muscle strength. The fat fractions were also tested for association with sex, BMI, physical activity and lower back pain.

RESULTS: Both paraspinal and leg fat fractions correlated directly with age (p<0.0001). At all ages, fat fraction was higher in paraspinal than leg muscles. The age-related increase in fat fraction was higher in paraspinal muscles than leg muscles (p<0.0001). The CSA of the muscles did not correlate with age. Knee extension strength correlated with fat fraction (p<0.05), and the muscle strength of hip muscles, thigh muscles and anterior calf muscles correlated with CSA (p<0.05). Sex was associated with lumbar paraspinal fat fraction (p<0.05) and BMI with thigh fat fraction (p<0.001). There was no association between fat fraction and physical activity or lower back pain.

CONCLUSION: The paraspinal muscles were more susceptible to age-related changes than leg muscles. Further, men had significantly lower fat fractions in lumbar paraspinal muscles and BMI was positively associated with thigh, but not paraspinal, fat fraction.

OriginalsprogEngelsk
TidsskriftMedicine and Science in Sports and Exercise
Vol/bind49
Udgave nummer3
Sider (fra-til)596-601
ISSN0195-9131
DOI
StatusUdgivet - 2017

ID: 49294082