Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Familial risk and heritability of depression by age at first diagnosis in Danish twins

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Reducing the rate of psychiatric Re-ADMISsions in Bipolar Disorder using smartphones The RADMIS trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Hippocampal Volume and Memory Impairment after Electroconvulsive Therapy in Patients with Depression

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The Validity of Child and Adolescent Depression Diagnoses in the Danish Psychiatric Central Research Register

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. High suicide rates during psychiatric inpatient stay and shortly after discharge

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Oral contraceptives and the serotonin 4 receptor: a molecular brain imaging study in healthy women

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Reward processing in major depressive disorder and prediction of treatment response - Neuropharm study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Treatment-resistant depression and risk of all-cause mortality and suicidality in Danish patients with major depression

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Body mass index and height in relation to type 2 diabetes by levels of intelligence and education in a large cohort of Danish men

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Kan prævention udløse depression?

    Publikation: Bidrag til tidsskriftLeder

  5. Are Advances in Survival among the Oldest Old Seen across the Spectrum of Health and Functioning?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVE: Familial and genetic factors seem to contribute to the development of depression but whether this varies with age at diagnosis remains unclear. We examined the influence of familial factors on the risk of depression by age at first diagnosis.

METHODS: We included 23,498 monozygotic and 39,540 same-sex dizygotic twins from the population-based Danish Twin Registry, followed from 1977 through 2011 in nationwide registers. We used time-to-event analyses accounting for censoring and competing risk of death to estimate cumulative incidence, casewise concordance, relative recurrence risk, and heritability of first depression by age using monozygotic and same-sex dizygotic twin pairs.

RESULTS: During follow-up, a total of 1545 twins were diagnosed with depression. For twins at age 35 or younger at first depression, heritability was estimated to be 24.8% (95% confidence interval [CI], 4.6-43.1%), whereas at age 90 it was 14.7% (95% CI, 3.1-26.3%). The relative recurrence risk was higher at younger ages: at age 35 the risk was 27.7-fold (95% CI, 20.0-35.5) and 6.9-fold (95% CI, 3.9-9.8) higher than the population risk for monozygotic and same-sex dizygotic twins, respectively, while the corresponding numbers were 3.0 (95% CI, 2.3-3.6) and 1.8 (95% CI, 1.3-2.2) at age 90. Heritability seemed similar for male and female twins.

CONCLUSION: Familial risk of depression, caused either by genes or shared environment, seemed to slightly decrease with age at diagnosis and an elevated concordance risk for monozygotic over same-sex dizygotic pairs suggested a genetic contribution to the development of depression.

OriginalsprogEngelsk
TidsskriftActa Psychiatrica Scandinavica
Vol/bind142
Udgave nummer6
Sider (fra-til)446-455
Antal sider10
ISSN0001-690X
DOI
StatusUdgivet - dec. 2020

Bibliografisk note

This article is protected by copyright. All rights reserved.

ID: 60965282