Familial hypercholesterolaemic downsized pig with human-like coronary atherosclerosis: a model for preclinical studies

Troels Thim; Mette Kallestrup Hagensen; Ludovic Drouet; Claire Bal Dit Sollier; Michel Bonneau; Juan F Granada; Lars Bo Nielsen; William Paaske; Hans Erik Bøtker; Erling Falk

doi:10.4244/

Familial hypercholesterolaemic downsized pig with human-like coronary atherosclerosis: a model for preclinical studies

Troels Thim, Mette Kallestrup Hagensen, Ludovic Drouet, Claire Bal Dit Sollier, Michel Bonneau, Juan F Granada, Lars Bo Nielsen, William Paaske, Hans Erik Bøtker, Erling Falk

Afdeling for Klinisk Biokemi

59 Citationer (Scopus)

Abstrakt

A manageable and reproducible large animal model of human-like coronary atherosclerosis is lacking but highly needed for translational research in percutaneous coronary interventions and imaging. Farm pigs with familial hypercholesterolaemia develop advanced atherosclerosis in two to three years but then weigh >200 kg making them impractical and costly. We aimed at down-sizing this pig and accelerating coronary plaque development to make the model more useful and affordable.

Originalsprog	Engelsk
Tidsskrift	EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
Vol/bind	6
Udgave nummer	2
Sider (fra-til)	261-8
Antal sider	8
DOI	https://doi.org/10.4244/
Status	Udgivet - 1 jun. 2010

Adgang til dokumentet

10.4244/

Citationsformater

Thim, T., Hagensen, M. K., Drouet, L., Bal Dit Sollier, C., Bonneau, M., Granada, J. F., Nielsen, L. B., Paaske, W., Bøtker, H. E., & Falk, E. (2010). Familial hypercholesterolaemic downsized pig with human-like coronary atherosclerosis: a model for preclinical studies. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 6(2), 261-8. https://doi.org/10.4244/

Familial hypercholesterolaemic downsized pig with human-like coronary atherosclerosis: a model for preclinical studies. / Thim, Troels; Hagensen, Mette Kallestrup; Drouet, Ludovic et al.

I: EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Bind 6, Nr. 2, 01.06.2010, s. 261-8.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Thim, T, Hagensen, MK, Drouet, L, Bal Dit Sollier, C, Bonneau, M, Granada, JF, Nielsen, LB, Paaske, W, Bøtker, HE & Falk, E 2010, 'Familial hypercholesterolaemic downsized pig with human-like coronary atherosclerosis: a model for preclinical studies', EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, bind 6, nr. 2, s. 261-8. https://doi.org/10.4244/

Thim T, Hagensen MK, Drouet L, Bal Dit Sollier C, Bonneau M, Granada JF et al. Familial hypercholesterolaemic downsized pig with human-like coronary atherosclerosis: a model for preclinical studies. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology. 2010 jun. 1;6(2):261-8. https://doi.org/10.4244/

@article{a2396fd34dd643ec98f4d608da1b6115,

title = "Familial hypercholesterolaemic downsized pig with human-like coronary atherosclerosis: a model for preclinical studies",

abstract = "A manageable and reproducible large animal model of human-like coronary atherosclerosis is lacking but highly needed for translational research in percutaneous coronary interventions and imaging. Farm pigs with familial hypercholesterolaemia develop advanced atherosclerosis in two to three years but then weigh >200 kg making them impractical and costly. We aimed at down-sizing this pig and accelerating coronary plaque development to make the model more useful and affordable.",

author = "Troels Thim and Hagensen, {Mette Kallestrup} and Ludovic Drouet and {Bal Dit Sollier}, Claire and Michel Bonneau and Granada, {Juan F} and Nielsen, {Lars Bo} and William Paaske and B{\o}tker, {Hans Erik} and Erling Falk",

year = "2010",

month = jun,

day = "1",

doi = "10.4244/",

language = "English",

volume = "6",

pages = "261--8",

journal = "EuroIntervention",

issn = "1774-024X",

publisher = "Europa Edition",

number = "2",

}

TY - JOUR

T1 - Familial hypercholesterolaemic downsized pig with human-like coronary atherosclerosis: a model for preclinical studies

AU - Thim, Troels

AU - Hagensen, Mette Kallestrup

AU - Drouet, Ludovic

AU - Bal Dit Sollier, Claire

AU - Bonneau, Michel

AU - Granada, Juan F

AU - Nielsen, Lars Bo

AU - Paaske, William

AU - Bøtker, Hans Erik

AU - Falk, Erling

PY - 2010/6/1

Y1 - 2010/6/1

N2 - A manageable and reproducible large animal model of human-like coronary atherosclerosis is lacking but highly needed for translational research in percutaneous coronary interventions and imaging. Farm pigs with familial hypercholesterolaemia develop advanced atherosclerosis in two to three years but then weigh >200 kg making them impractical and costly. We aimed at down-sizing this pig and accelerating coronary plaque development to make the model more useful and affordable.

AB - A manageable and reproducible large animal model of human-like coronary atherosclerosis is lacking but highly needed for translational research in percutaneous coronary interventions and imaging. Farm pigs with familial hypercholesterolaemia develop advanced atherosclerosis in two to three years but then weigh >200 kg making them impractical and costly. We aimed at down-sizing this pig and accelerating coronary plaque development to make the model more useful and affordable.

U2 - 10.4244/

DO - 10.4244/

M3 - Journal article

C2 - 20562079

VL - 6

SP - 261

EP - 268

JO - EuroIntervention

JF - EuroIntervention

SN - 1774-024X

IS - 2

ER -

Familial hypercholesterolaemic downsized pig with human-like coronary atherosclerosis: a model for preclinical studies

Abstrakt

Adgang til dokumentet

Fingeraftryk

Citationsformater