Familial hypercholesterolaemic downsized pig with human-like coronary atherosclerosis: a model for preclinical studies

Troels Thim, Mette Kallestrup Hagensen, Ludovic Drouet, Claire Bal Dit Sollier, Michel Bonneau, Juan F Granada, Lars Bo Nielsen, William Paaske, Hans Erik Bøtker, Erling Falk

62 Citationer (Scopus)

Abstract

A manageable and reproducible large animal model of human-like coronary atherosclerosis is lacking but highly needed for translational research in percutaneous coronary interventions and imaging. Farm pigs with familial hypercholesterolaemia develop advanced atherosclerosis in two to three years but then weigh >200 kg making them impractical and costly. We aimed at down-sizing this pig and accelerating coronary plaque development to make the model more useful and affordable.
OriginalsprogEngelsk
TidsskriftEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
Vol/bind6
Udgave nummer2
Sider (fra-til)261-8
Antal sider8
DOI
StatusUdgivet - 1 jun. 2010

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